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Contributions of experimental mouse models to the understanding of African trypanosomiasis. Vrije Universiteit Brussel

Nicolas Antoine-Moussiaux, Stefan Magez, Daniel Desmecht
African trypanosomiasis is the collective name for a wide variety of trypanosome infections that affect humans and livestock. In recent years, experimental mice infection models have provided new insights into both human and animal trypanosomiasis. Mouse models seem to be a valuable and versatile tool in trypanosomiasis-associated pathology and immunology research and highlight the variety shown by African trypanosomiases. Indeed, inbred mouse ...

Nucleoside analogues for the treatment of animal trypanosomiasis Universiteit Gent Universiteit Antwerpen

Dorien Mabille, Kayhan Ilbeigi, Sarah Hendrickx, Marzuq A. Ungogo, Fabian Hulpia, Cai Lin, Louis Maes, Harry P. de Koning, Serge Van Calenbergh, Guy Caljon, et al.
Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleosides for the treatment of AT. Promising hits were identified with excellent in vitro activity across all important animal trypanosome species. Compound 7, an inosine analogue, and our previously ...

African trypanosomiasis Universiteit Gent

Stefan Magez, Hang Nguyen Thi Thu, Joar Esteban Pinto Torres, Magdalena Radwanska
African trypanosomiasis is caused by salivarian trypanosomes that are extracellular parasites affecting humans, livestock and game animals around the world. There are only three salivarian trypanosomes that can infect humans. Both Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense cause human African trypanosomosis (HAT) or ‘sleeping sickness’. Trypanosoma evansi is the third salivarian trypanosome that has been identified in ...

Performance of clinical signs and symptoms, rapid and reference laboratory diagnostic tests for diagnosis of human African trypanosomiasis by passive screening in Guinea: a prospective diagnostic accuracy study Instituut voor Tropische Geneeskunde

Oumou Camara, Mamadou Camara, Laura Cristina Falzon, Hamidou Ilboudo, Jacques Kaboré, Charlie Franck Alfred Compaoré, Eric Maurice Fèvre, Philippe Büscher, Bruno Bucheton, Veerle Lejon, et al.

BACKGROUND: Passive diagnosis of human African trypanosomiasis (HAT) at the health facility level is a major component of HAT control in Guinea. We examined which clinical signs and symptoms are associated with HAT, and assessed the performance of selected clinical presentations, of rapid diagnostic tests (RDT), and of reference laboratory tests on dried blood spots (DBS) for diagnosing HAT in Guinea.

METHOD: The study took place in ...

Costs and outcomes of integrated Human African Trypanosomiasis surveillance system using rapid diagnostic tests, Democratic Republic of the Congo Instituut voor Tropische Geneeskunde

Rian Snijders, Alain Fukinsia, Yves Claeys, Epco Hasker, Alain Mpanya, Erick Mwamba Miaka, Filip Meheus, Marleen Boelaert

We integrated sleeping sickness case detection into the primary healthcare system in 2 health districts in the Democratic Republic of the Congo. We replaced a less field-friendly serologic test with a rapid diagnostic test, which was followed up by human African trypanosomiasis microscopic testing, and used a mixed costing methodology to estimate costs from a healthcare provider perspective. We screened a total of 18,225 persons and ...

Gambiense human african trypanosomiasis and immunological memory Instituut voor Tropische Geneeskunde

Veerle Lejon, Dieudonné Mumba-Ngoyi, L Kestens, L. Boel, Barbara Barbé, Victor Kande Betu, Johan van Griensven, Emmanuel Bottieau, Jean-Jacques Muyembe, Jan Jacobs, et al.

In mice, experimental infection with Trypanosoma brucei causes decreased bone marrow B-cell development, abolished splenic B-cell maturation and loss of antibody mediated protection including vaccine induced memory responses. Nothing is known about this phenomenon in human African trypanosomiasis (HAT), but if occurring, it would imply the need of revaccination of HAT patients after therapy and abolish hope for a HAT vaccine. The effect of ...

Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: a longitudinal follow-up study Instituut voor Tropische Geneeskunde

Ipos Ngay Lukusa, Nick Van Reet, Dieudonné Mumba-Ngoyi, Erick Mwamba Miaka, Justin Masumu, Pati Patient Pyana, Wilfried Mutombo, Digas Ngolo, Vincent Kobo, Felix Akwaso, et al.

BACKGROUND: Detection of spliced leader (SL)-RNA allows sensitive diagnosis of gambiense human African trypanosomiasis (HAT). We investigated its diagnostic performance for treatment outcome assessment.

METHODS: Blood and cerebrospinal fluid (CSF) from a consecutive series of 97 HAT patients, originating from the Democratic Republic of the Congo, were prospectively collected before treatment with acoziborole, and during 18 months of ...

African trypanosomiasis and antibodies : implications for vaccination, therapy and diagnosis Universiteit Gent

Stefan Magez, Magdalena Radwanska
African trypanosomiasis causes devastating effects on human populations and livestock herds in large parts of sub-Saharan Africa. Control of the disease is hampered by the lack of any efficient vaccination results in a field setting, and the severe side effects of current drug therapies. In addition, with the exception of Trypanosoma brucei gambiense infections, the diagnosis of trypanosomiasis has to rely on microscopic analysis of blood ...