Publicaties

Ultra-High dose -per-pulse regimens (UHDP), necessary to trigger the "FLASH" effect, still pose serious challenges to dosimetry. Dosimetry plays a crucial role, both to significantly improve the accuracy of the radiobiological experiments necessary to fully understand the mechanisms underlying the effect and its dependencies on the beam parameters, and to be able to translate such effect into clinical practice. The standard ionization chamber in ...

Radiotherapy is part of the treatment of over 50% of cancer patients. Its efficacy is limited by the radiotoxicity to the healthy tissue. FLASH-RT is based on the biological effect that ultra-high dose rates (UHDR) and very short treatment times strongly reduce normal tissue toxicity, while preserving the anti-tumoral effect. Despite many positive preclinical results, the translation of FLASH-RT to the clinic is hampered by the lack of accurate ...

Oligodendrocyte precursor cells (OPCs) constitute the main proliferative cells in the adult brain, and deregulation of OPC proliferation-differentiation balance results in either glioma formation or defective adaptive (re)myelination. OPC differentiation requires significant genetic reprogramming, implicating chromatin remodeling. Mounting evidence indicates that chromatin remodelers play important roles during normal development and their ...

High dynamic range (HDR) image generation from a number of differently exposed low dynamic range (LDR) images has been extensively explored in the past few decades, and as a result of these efforts a large number of HDR synthesis methods have been proposed. Since HDR images are synthesized by combining well-exposed regions of the input images, one of the main challenges is dealing with camera or object motion. In this paper we propose a method ...

In high dynamic range (HDR) imaging, multiple photographs with different exposure times are combined into a radiance map, which reflects the radiance in real-life scenes. This involves recovering the response function of the imaging process. The technique proposed by Debevec and Malik is a well-known HDR image synthesis algorithm, but the computational complexity is relatively high, which limits the possible image size and the reconstruction ...

Multi-exposure high dynamic range(HDR) imaging
builds HDR radiance maps by stitching together different
views of a same scene with varying exposures.
Practically, this process involves converting raw sensor
data into low dynamic range (LDR) images, estimate the
camera response curves, and use them in order to recover
the irradiance for every pixel. During the export, applying
white balance settings and image ...

High Dynamic Ranges (HDR) displays can show images with higher color contrast levels and peak luminosities than the commonly used Low Dynamic Range (LDR) displays. Although HDR displays are still expensive, they are reaching the consumer market in the coming years. Unfortunately, most video content is recorded and/or graded in LDR format. Typically, dynamic range expansion by using an Inverse Tone Mapped Operator (iTMO) is required to show LDR ...

Multi-exposure image fusion (MEF) methods for high dynamic range (HDR) imaging suffer from ghosting artifacts when dealing with moving objects in dynamic scenes. The state-of-the-art methods use optical flow to align low dynamic range (LDR) images before merging, introducing distortion into the aligned LDR images from inaccurate motion estimation due to large motion and occlusion. In place of pre-alignment, attention-based methods calculate the ...

Abstract Due to the ongoing miniaturization of digital camera sensors and the steady increase of the “number of megapixels”, individual sensor elements of the camera become more sensitive to noise, even deteriorating the final image quality. To go around this problem, sophisticated processing algorithms in the devices, can help to maximally exploit the knowledge on the sensor characteristics (e.g., in terms of noise), and offer a better image ...