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An improved microbore UHPLC method with electrochemical detection for the simultaneous determination of low monoamine levels in in vivo brain microdialysis samples. Vrije Universiteit Brussel
The simultaneous determination of the monoamines dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in in vivo microdialysis samples remains challenging because of the low extracellular neurotransmitter levels in different brain regions, specific sample characteristics, and the quest for high temporal resolution and a multi-target strategy in neuropharmacological research. A fast and sensitive microbore (1.0 mm i.d. column) UHPLC method ...
Generic UHPLC method for the simultaneous analysis of compounds with a wide range of polarities Universiteit Antwerpen KU Leuven Vrije Universiteit Brussel
Appropriate analytical methods are required to evaluate the presence, metabolism, degradation, and removal of specific compounds in complex mixtures. There is an increasing demand to analyze samples with a wide range of polarities in a variety of applications, including environmental analysis, biomarker discovery, and proteomics. Multiple analyses on complementary columns are often needed to cover the separation of all compounds with a large ...
Generic UHPLC Method for the Simultaneous Analysis of Compounds with a Wide Range of Polarities Vrije Universiteit Brussel KU Leuven
Appropriate analytical methods are required to evaluate the presence, metabolism, degradation, and removal of specific compounds in complex mixtures. There is an increasing demand to analyze samples with a wide range of polarities in a variety of applications, including environmental analysis, biomarker discovery, and proteomics. Multiple analyses on complementary columns are often needed to cover the separation of all compounds with a large ...
Improving the LC-MS/MS analysis of neuromedin U-8 and neuromedin S by minimizing their adsorption behavior and optimizing UHPLC and MS parameters Vrije Universiteit Brussel
Neuromedin U (NmU) and neuromedin S (NmS) are two closely related neuropeptides belonging to the neuromedin family. NmU usually occurs either as a truncated eight amino acid long peptide (NmU-8) or as an 25 amino acid long peptide, although other molecular forms exist depending on the species considered. NmS, on the other hand, is a 36 amino acid long peptide, sharing the same amidated C-terminal heptapeptide with NmU. Nowadays, liquid ...
UHPLC coupled to hybrid high resolution MS for digestion metabolomics and DNA adductomics Universiteit Gent
Use of UHPLC high-resolution Orbitrap mass spectrometry to investigate the genes involved in the production of secondary metabolites in Aspergillus flavus Universiteit Gent
Quantification and profiling of lipophilic marine toxins in microalgae by UHPLC coupled to high-resolution orbitrap mass spectrometry Universiteit Gent
Screening for DNA adducts in meat digests with UHPLC coupled to high-resolution Orbitrap mass spectrometry in colorectal cancer research Universiteit Gent
UHPLC coupled with Fourier transform Orbitrap for residue analysis Universiteit Gent
The trend in residue analysis has changed from target-oriented procedures - mainly based on liquid chromatography combined with triple-quadrupole mass spectrometric (MS) detection - towards accurate mass full-scan MS techniques [e.g., time-of-flight (TOF) and Fourier transform mass spectrometry (FT-M,S)]. Full-scan MS approaches allow the retrospective evaluation of old data and support multi-residue applications, including different classes of ...