Publicaties

We describe the fabrication and characterization of large-area active-matrix X-ray/photodetector array of high quality using organic photodiodes and organic transistors. All layers with the exception of the electrodes are solution processed. Because it is processed on a very thin plastic substrate of 25 mu;m thickness, the photodetector is only 100 mu;m thick. When combined with an 300-μm-thick X-ray scintillator, this gives a thin, low-weight ...

We demonstrate organic imaging sensor arrays fabricated on flexible plastic foil with the solution processing route for both photodiodes and thin film transistors. We used the photovoltaic P3HT:PCBM blend for fabricating the photodiodes using spin coating and pentacene as semiconductor material for the TFTs. Photodiodes fabricated with P3HT:PCBM absorb in the green part of the visible spectrum which matches with the typical scintillator output ...

The cyclopentenone prostaglandin A1 (PGA1) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA1 triggers apoptosis by a process that entails the specific activation of H- and N-Ras isoforms, leading to caspase activation. Cells without H- and N-Ras did not undergo apoptosis upon PGA1 treatment; in these cells, the cellular demise was rescued by ...

Ionizing radiation (IR) used in clinical diagnosis contributes to 53% of the radiation burden to the Belgian population. IR, such as x-rays, is known to induce cancer at high doses, but the effect at low doses is less clear. Clarification of low-dose health consequences is needed and is the subject of this PhD research, which fits well with the goals of the High Level and Expert Group on European Low Dose Risk Research. The first part of the PhD ...

We present the new X-ray functionalities of the skirt radiative transfer code, forming an advanced tool to study cold dusty gas in active galactic nuclei (AGN), with a particular focus on complex three-dimensional transfer media. Focusing on the X-ray broadband spectra of obscured AGN, skirt incorporates scattering on free electrons, absorption and fluorescence by cold gas, scattering on bound electrons, as well as absorption and scattering by ...

Purpose: In many countries, breast cancer screening programs based on periodic mammography exist, giving a large group of women regularly a small dose of ionizing radiation. In order to assess the benefit/risk ratio of those programs the relative biological effectiveness (RBE) of mammography X-rays needs to be determined. Materials and methods: Blood of five healthy donors was irradiated in vitro with 30 kV X-rays and Co-60 gamma-rays with doses ...

Understanding the differences in biological response to photon and particle radiation is important for optimal exploitation of particle therapy for cancer patients, as well as for the adequate application of radiation protection measures for astronauts. To address this need, we compared the transcriptional profiles of isolated peripheral blood mononuclear cells 8 h after exposure to 1 Gy of X-rays, carbon ions or iron ions with those of ...

Liquid migration inside building materials is influenced by the microstructure of the porous medium and by the physical characteristics of the solids and the fluids that occupy its pore space. Understanding the relationship between microstructure and transport is of great theoretical and practical interest since this has an influence on the macroscopical behaviour of a building material. Highly advanced imaging techniques like high-resolution ...

Introduction: In radiology, low X-ray energies (<140 keV) are used to obtain an optimal image while in radiotherapy, higher X-ray energies (MeV) are used to eradicate tumor tissue. In radiation research, both these X-ray energies being used to extrapolate in vitro research to clinical practice. However, the energy deposition of X-rays depends on their energy spectrum, which might lead to changes in biological response. Therefore, this study ...