Publicaties
Challenges and knowledge gaps in the management of non-tuberculous mycobacterial pulmonary disease in sub-Saharan African countries with a high tuberculosis burden: a scoping review Instituut voor Tropische Geneeskunde Universiteit Antwerpen KU Leuven
INTRODUCTION: In sub-Saharan African (SSA) countries endemic for tuberculosis (TB), previous TB is a significant risk factor for non-tuberculous mycobacterial pulmonary disease (NTM-PD). The deployment of GeneXpert MTB/RIF in pulmonary TB diagnostic work-up regularly identifies symptomatic patients with a positive smear microscopy but negative GeneXpert, indicative of NTM presence. This scoping review outlines recent evidence for NTM-PD ...
Exploratory results of intensification of the use of the GeneXpert (R) MTB/RIF as support in the tracking the TB and TB-RR in Kinshasa Instituut voor Tropische Geneeskunde
String test : a potentially useful tool in the diagnosis of pulmonary tuberculosis in Brazilian children and adolescents Universiteit Gent
Spot specimen testing with GeneXpert MTB/RIF results compared to morning specimen in a programmatic setting in Cotonou, Benin Instituut voor Tropische Geneeskunde
BACKGROUND: The diagnosis of tuberculosis (TB) using smear microscopy has been based on testing two specimens: one spot and one early morning sputa. Recently, the World Health Organization (WHO) has recommended to replace, whenever possible, microscopy with GeneXpert® MTB/RIF performed on a single specimen. However, as the bacterial load is higher in early morning specimens than in spot specimens, one could expect lower sensitivity of ...
Classical and new assays for detecting drug resistance in tuberculosis Universiteit Gent
Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults Universiteit Hasselt KU Leuven
Computer-aided detection thresholds for digital chest radiography interpretation in tuberculosis diagnostic algorithms Instituut voor Tropische Geneeskunde
OBJECTIVES: Use of computer-aided detection (CAD) software is recommended to improve tuberculosis screening and triage, but threshold determination is challenging if reference testing has not been performed in all individuals. We aimed to determine such thresholds through secondary analysis of the 2019 Lesotho national tuberculosis prevalence survey.
METHODS: Symptom screening and chest radiographs were performed in participants aged ...
The detection of mutations and genotyping of drug-resistant Mycobacterium tuberculosis strains isolated from patients in the rural eastern Cape Province Universiteit Antwerpen
Implementation of the advanced HIV disease care package with point-of-care CD4 testing during tuberculosis case finding: a mixed-methods evaluation Instituut voor Tropische Geneeskunde Universiteit Antwerpen
During TB-case finding, we assessed the feasibility of implementing the advanced HIV disease (AHD) care package, including VISITECT CD4 Advanced Disease (VISITECT), a semiquantitative test to identify a CD4≤200cells/μl. Adult participants with tuberculosis symptoms, recruited near-facility in Lesotho and South-Africa between 2021-2022, were offered HIV testing (capillary blood), Xpert MTB/RIF and Ultra, and MGIT culture (sputum). People ...