Histone Deacetylase 6 (HDAC6) as therapeutic target in axonal Charcot-Marie-Tooth disease KU Leuven
Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system, affecting 1 in 2500 people. Progressive degeneration of the motor nerves leads to the development of motor problems such as muscle wasting and weakness, steppage gate and deformities of hand and feet. Also the sensory nerves are affected leading to reduced sensation of touch, pain and temperature. When only motor axons are affected, the ...