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Accelerated rTMS Vrije Universiteit Brussel Universiteit Gent

Chris Baeken

Three decades of clinical research on repetitive transcranial magnetic stimulation (rTMS) has yielded one clear treatment indication in psychiatry for major depression disorder (MDD). Although the clinical response equals the standard treatment algorithms, the effect sizes on the beneficial outcome remain rather modest. Over the last couple of years, to improve the efficacy in resistant depression, two new avenues have been developed: ...

Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression Universiteit Gent Vrije Universiteit Brussel

GuoU+2010Rong Wu, Xiaowan Wang, Chris Baeken
Although in theory sham repetitive transcranial magnetic stimulation (rTMS) has no inherent therapeutic value, nonetheless, such placebo stimulations may have relevant therapeutic effects in clinically depressed patients. On the other hand, antidepressant responses to sham rTMS are quite heterogeneous across individuals and its neural underpinnings have not been explored yet. The current brain imaging study aims to detect baseline neural ...

Accelerated high frequency rTMS induces time-dependent dopaminergic alterations Vrije Universiteit Brussel Universiteit Gent

Sofie Salden, Kurt Audenaert, Ann Van Eeckhaut, Dimitri De Bundel, Chris Baeken

AIM: The neurobiological effects of repetitive transcranial magnetic stimulation are believed to run in part through the dopaminergic system. Accelerated high frequency rTMS (aHF-rTMS), a new form of stimuli delivery, is currently being tested for its usefulness in treating human and canine mental disorders. However, the short-and long-term neurobiological effects are still unclear, including the effects on the dopaminergic system. In ...

The impact of accelerated high frequency rTMS on brain neurochemicals in treatment-resistant depression: Insights from H-1 MR spectroscopy Vrije Universiteit Brussel Universiteit Gent

Chris Baeken, Jean-Pascal Lefaucheur, Peter Van Schuerbeek

OBJECTIVE: Although accelerated repetitive transcranial magnetic stimulation (rTMS) designs seem to be able to alleviate mood over a relatively short period of time, no studies yet examined the cellular effects on neurochemicals with regard to working mechanisms, safety and neural integrity.

METHODS: Eighteen right-handed antidepressant-free unipolar treatment resistant depressed (TRD) patients participated in this sham-controlled ...

Accelerated rTMS in the treatment of obsessive compulsive disorder: A pilot study on safety and feasibility Vrije Universiteit Brussel

Hannelore Ln Tandt, Sara De Witte, Josefien Dedoncker, Nicolas Van de Velde, Nicolas De Schryver, Gilbert M. D. Lemmens, K Audenaert, Chris Baeken
Introduction: Obsessive Compulsive Disorder (OCD) is a disabling psychiatric disorder with a prevalence of approximately 1–3%. Next to disruptions within the orbitofronto-subcortical loops, regions within the salience network (SN) are related to specific OCD symptoms. Of interest, non-invasive brain stimulation has been documented to modulate SN cortical-subcortical loop disturbances. Therefore medial prefrontal regions (supplementary motor area ...

Indirect frontocingulate structural connectivity predicts clinical response to accelerated rTMS in major depressive disorder Universiteit Gent Vrije Universiteit Brussel

Deborah Klooster, Iris N. Vos, Karen Caeyenberghs, Alexander Leemans, Szabolcs David, René M.H. Besseling, Albert P. Aldenkamp, Chris Baeken
Background: Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), but its clinical efficacy remains rather modest. One reason for this could be that the propagation of rTMS effects via structural connections from the stimulated area to deeper brain structures (such as the cingulate cortices) is suboptimal. Methods: We investigated whether structural connectivity - derived from ...

The Impact of Accelerated Right Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Cue-Reactivity Vrije Universiteit Brussel Universiteit Gent

Sarah Herremans, Peter Van Schuerbeek, Rudi De Raedt, Frieda Matthys, Ronald Buyl, Johan De Mey, Chris Baeken

In alcohol-dependent patients craving is a difficult-to-treat phenomenon. It has been suggested that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may have beneficial effects. However, exactly how this application exerts its effect on the underlying craving neurocircuit is currently unclear. In an effort to induce alcohol craving and to maximize detection of HF-rTMS effects to cue-induced alcohol craving, patients ...