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Lower rate of major bleeding in very high risk patients undergoing left atrial appendage occlusion: A propensity score–matched comparison with direct oral anticoagulant Vrije Universiteit Brussel

Michele Magnocavallo, Domenico Giovanni Della Rocca, Giampaolo Vetta, Sanghamitra Mohanty, Carola Gianni, Marco Polselli, Pietro Rossi, Antonio Parlavecchio, Vincenzo Mirco La Fazia, Fabrizio Guarracini, et al.

BACKGROUND: Long-term oral anticoagulation is the mainstay therapy for thromboembolic (TE) prevention in patients with atrial fibrillation (AF). However, left atrial appendage occlusion (LAAO) could be a safe alternative to direct oral anticoagulants (DOACs) in patients with a very high thromboembolic risk profile.

OBJECTIVE: to compare the safety and efficacy of LAAO versus DOACs among AF patients at very high stroke risk ...

Modification of the terms of authorisation regarding the additive consisting of liquid l-lysine base produced with Corynebacterium glutamicum NRRL B-67439 and NRRL B-67535 for all animal species (ADM specialty ingredients (Europe) B.V.). Instituut voor Landbouw-, Visserij- en Voedingsonderzoek

Lieve Herman
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of liquid l-lysine base produced with a genetically modified strain of Corynebacterium glutamicum as a nutritional feed additive for all animal species. The l-lysine base liquid produced with C. glutamicum NRRL B-67535 and NRRL B-67439 is ...

Generative AI unlocks PET insights: brain amyloid dynamics and quantification Vrije Universiteit Brussel

Matías Nicolás Bossa Bossa, Akshaya Ganesh Nakshathri, Abel Diaz Berenguer, Hichem Sahli
Introduction: Studying the spatiotemporal patterns of amyloid accumulation in the brain over time is crucial in understanding Alzheimer's disease (AD). Positron Emission Tomography (PET) imaging plays a pivotal role because it allows for the visualization and quantification of abnormal amyloid beta (Aβ) load in the living brain, providing a powerful tool for tracking disease progression and evaluating the efficacy of anti-amyloid therapies. ...

PO-02-146 PERICARDITIS PROPHYLACTIC THERAPY AFTER SINUS NODE SPARING HYBRID ABLATION FOR INAPPROPRIATE SINUS TACHYCARDIA / POSTURAL ORTHOSTATIC SINUS TACHYCARDIA Vrije Universiteit Brussel

C. De Asmundis, Lorenzo Marcon, Luigi Pannone, Domenico Giovanni Della Rocca, Cinzia Monaco, Antonio Sorgente, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Stroker, et al.
Background: Pericarditis is the most common complication following hybrid sinus node sparing ablation for Inappropriate Sinus Tachycardia (IST)/Postural Orthostatic Tachycardia Syndrome (POTS). Objective: To evaluate the impact of prophylaxis therapy on the risk of symptomatic pericarditis following hybrid IST/POTS ablation. Methods: All consecutive patients undergoing to hybrid ablation of symptomatic IST/POTS refractory or intolerant to drugs ...

The microbial and metabolite composition of Gouda cheese made from pasteurized milk is determined by the processing chain Vrije Universiteit Brussel

Hannes Decadt, Stefan Weckx, Luc De Vuyst
Gouda cheeses of different production batches and ripening times often differ in metabolite composition, which may be due to the starter culture mixture applied or the growth of non-starter lactic acid bacteria (NSLAB) upon maturation. Therefore, a single Gouda cheese production batch was systematically investigated from the thermized milk to the mature cheeses, ripened for up to 100 weeks, to identify the main bacterial species and metabolites ...

Leucine Motifs Stabilize Residual Helical Structure in Disordered Proteins Vrije Universiteit Brussel

Uroš Zavrtanik, Tadej Medved, Samo Purič, Wim Vranken, Jurij Lah, San Hadži

Many examples are known of regions of intrinsically disordered proteins that fold into α-helices upon binding to their targets. These helical binding motifs (HBMs) can be partially helical also in the unbound state, and this so-called residual structure can affect binding affinity and kinetics. To investigate the underlying mechanisms governing the formation of residual helical structure, we assembled a dataset of experimental helix contents ...

Pericarditis prophylactic therapy after sinus node–sparing hybrid ablation for inappropriate sinus tachycardia/postural orthostatic sinus tachycardia Vrije Universiteit Brussel

C. De Asmundis, Lorenzo Marcon, Luigi Pannone, Domenico Giovanni Della Rocca, Dhanunjaya Lakkireddy, Thomas M Beaver, Chad R Brodt, Cinzia Monaco, Antonio Sorgente, Charles Audiat, et al.
Background: Pericarditis is the most common complication following hybrid sinus node–sparing ablation for inappropriate sinus tachycardia (IST)/postural orthostatic tachycardia syndrome (POTS). Objective: The study sought to evaluate the association of prophylaxis therapy on the risk of symptomatic pericarditis following hybrid IST/POTS ablation. Methods: All consecutive patients undergoing to hybrid ablation of symptomatic IST/POTS refractory ...

Pericarditis prophylactic therapy after sinus mode–sparing hybrid ablation for inappropriate sinus tachycardia/postural orthostatic sinus tachycardia Vrije Universiteit Brussel

C. De Asmundis, Lorenzo Marcon, Luigi Pannone, Domenico Giovanni Della Rocca, Dhanunjaya Lakkireddy, Thomas M Beaver, Chad R Brodt, Cinzia Monaco, Antonio Sorgente, Charles Audiat, et al.

BACKGROUND: Pericarditis is the most common complication following hybrid sinus node-sparing ablation for inappropriate sinus tachycardia (IST)/postural orthostatic tachycardia syndrome (POTS).

OBJECTIVE: The study sought to evaluate the association of prophylaxis therapy on the risk of symptomatic pericarditis following hybrid IST/POTS ablation.

METHODS: All consecutive patients undergoing to hybrid ablation of symptomatic ...

Maternal liver-related symptoms during pregnancy in primary sclerosing cholangitis Universiteit Gent

Jeremy S Nayagam, Tobias J Weismüller, Piotr Milkiewicz, Karolina M Wronka, Emil Bik, Christoph Schramm, Katja Fuessel, Taotao Zhou, Johannes Chang, Martti Färkkilä, et al.
Background & Aims: Although worsening liver-related symptoms during pregnancy can occur in primary sclerosing cholangitis (PSC), there are insufficient data to effectively counsel patients on their pre-conception risk and no clear recommendations on monitoring and management during pregnancy. We aimed to describe maternal liver-related symptoms in pregnancy, both before and after PSC diagnosis, and explore factors associated with worsening ...

Stroomatlas Zeebrugge: deelrapport 15. Resultaten stationaire metingen Waterbouwkundig Laboratorium

Yves Plancke, Bart De Maerschalck
De meest recente stroomatlas van de haven van Zeebrugge dateert van 2011. Vanuit Port of Antwerp-Bruges is de vraag gekomen om een update te maken. Het Waterbouwkundig Laboratorium heeft hier gekozen voor een hybride aanpak van terreinmetingen en numerieke modellering.Voorliggend rapport presenteert de verwerkte stationaire stromingsmetingen van de meetcampagne die tussen 10 en 26 augustus 2023 door het Waterbouwkundig Laboratorium in ...