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Heterobifunctional PEG Ligands for Bioconjugation Reactions on Iron Oxide Nanoparticles KU Leuven
Ever since iron oxide nanoparticles have been recognized as promising scaffolds for biomedical applications, their surface functionalization has become even more important. We report the synthesis of a novel polyethylene glycol-based ligand that combines multiple advantageous properties for these applications. The ligand is covalently bound to the surface via a siloxane group, while its polyethylene glycol backbone significantly improves the ...
Water-soluble NHC-Cu catalysts : applications in click chemistry, bioconjugation and mechanistic analysis Universiteit Gent
CuAAC mediated Bioconjugation: The Rapid & Reliable Alternative to Today's Immobilization Protocols for Improved Hybrid Interfaces Universiteit Hasselt
During the last decade the copper catalysed azide alkyne cycloaddition (CuAAC) reaction has demonstrated its potential use in several research areas. The unique combination of properties, such as high specificity, high yields, minute side reactions, bio-orthogonality and the mild reaction conditions, in which the coupling reaction can take place, creates many opportunities for a wide variety of applications. The CuAAC has a lot to offer for ...
Bioconjugation: using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers Universiteit Gent
QUANTUM-CHEMICAL CALCULATION AND SPECTROSCOPIC STUDY OF pi-CONJUGATION PATHWAY IN NH-TAUTOMERS OF CORROLE FREE BASES Interuniversitair Micro-Electronica Centrum vzw Universiteit Hasselt
The pi-conjugation pathways were identtfied and the degrees of aromaticity for NH-tautomers of corrole free bases were determined by quantum chemistry methods and absorption spectroscopy. The macrocycle skeletal atoms participated differently in the formation of the pi-conjugation pathway. It was supposed that conjugation pathways consisting of 18 pi-electrons were dominant. At the same time, each of two NH-tautomers possessed its own distinct ...
Does Twisted pi-Conjugation Framework Always Induce Efficient Intersystem Crossing? A Case Study with Benzo[b]- and [a]Phenanthrene-Fused BODIPY Derivatives and Identification of a Dark State KU Leuven
The photophysical properties, especially the intersystem crossing (ISC) of two heavy-atom-free BODIPY derivatives with twisted π-conjugated frameworks (benzo[b]-fused BODIPY, BDP-B; and [a]phenanthrene-fused BODIPY, BDP-P), are studied with steady-state and time-resolved optical and electron paramagnetic resonance (TREPR) spectroscopic methods as well as with ADC(2) theoretical investigations. Interestingly, BDP-B has a planar π-conjugation ...
Quantum-Chemical Calculation and Spectroscopic Study if π-Conjugation Pathway in NH-Tautomers of Corrole Free Bases Universiteit Hasselt
The pi-conjugation pathways were identtfied and the degrees of aromaticity for NH-tautomers of corrole free bases were determined by quantum chemistry methods and absorption spectroscopy. The macrocycle skeletal atoms participated differently in the formation of the pi-conjugation pathway. It was supposed that conjugation pathways consisting of 18 pi-electrons were dominant. At the same time, each of two NH-tautomers possessed its own distinct ...
INVERSION OF AROMATICITY OF NH-TAUTOMERS OF FREE-BASE CORROLES IN THE LOWEST TRIPLET T-1-STATE Universiteit Hasselt
The aromaticity in the lowest triplet T-1-state of NH-tautomers of corrole free bases with different peripheral substitution architecture was investigated using quantum chemistry methods. It was established that the dominant pi-conjugation pathways differed for the NH-tautomers although the dominant pi-conjugation pathways in the ground singlet (S-0) and excited triplet (T-1) states for each of the two tautomers were the same. The degree of ...
Linker Molecules Convert Commercial Fluorophores into Tailored Functional Probes during Biolabelling KU Leuven
Many life-science techniques and assays rely on selective labeling of biological target structures with commercial fluorophores that have specific yet invariant properties. Consequently, a fluorophore (or dye) is only useful for a limited range of applications, e.g., as a label for cellular compartments, super-resolution imaging, DNA sequencing or for a specific biomedical assay. Modifications of fluorophores with the goal to alter their ...