Publicaties

According to the World Health Organization (WHO), nearly one in every six deaths worldwide is due to cancer, making it the number one death cause worldwide. Treating cancer is different for each person, and it depends on the type of cancer and how advanced it is. But for almost half of all cancer patients, a treatment called radiation therapy or radiotherapy is used at least once. This treatment option uses strong ionizing radiation to target ...

Objective. A novel solution is required for accurate 3D bioluminescence tomography (BLT) based glioblastoma (GBM) targeting. The provided solution should be computationally efficient to support real-time treatment planning, thus reducing the x-ray imaging dose imposed by high-resolution micro cone-beam CT. Approach. A novel deep-learning approach is developed to enable BLT-based tumor targeting and treatment planning for orthotopic rat GBM ...

Objective. Bioluminescence imaging (BLI) is a valuable tool for non-invasive monitoring of glioblastoma multiforme (GBM) tumor-bearing small animals without incurring x-ray radiation burden. However, the use of this imaging modality is limited due to photon scattering and lack of spatial information. Attempts at reconstructing bioluminescence tomography (BLT) using mathematical models of light propagation show limited progress. Approach. This ...