Projecten
microbiome-gebaseerde biomarkers om decompensatie van levercirrose en behandelingsreacties te voorspellen KU Leuven
Decompensation of liver cirrhosis and progression towards acute-on-chronic liver failure (ACLF) causes 1.2 million deaths/year. Microbiome is causally involved in cirrhosis progression and is for drugs the first interaction point with the patients. Drugs can alter the microbiome leading to unwanted effects or even facilitating their effects, but the microbiome metabolizes the drugs, shapes their effects and possibly determines the host ...
MoodBugs: hoe onze darmmicroben beïnvloeden hoe we ons voelen - bacteriële metabolieten en ontstekingen als bemiddelaars van menselijke microbiota-affectrelaties KU Leuven
Do our gut microbes influence our emotions? This sounded far-fetched a decade ago, but rodent research has shown that the microbial ecosystem in the gut (the gut microbiota) causally impacts affective processes. The underlying microbiota-gut-brain signalling mechanisms include the capacity of the microbiota to produce short-chain fatty acids (SCFA) from dietary fiber and to regulate inflammation.
These rodent findings have great ...
HealthFerm Innovatieve op puls en graan gebaseerde voedselfermentaties voor de menselijke gezondheid en duurzame voeding KU Leuven
Food fermentation has been used for millennia, but our knowledge on the impact of fermented foods on human health and the possible role of gut microbiota in it is limited. Microbial consortia and fermentation processes are, hence, not designed for optimal health outcomes. At the same time, fermentation technology represents a major opportunity to increase incorporation of plant-based proteins in diets.
The multi-actor consortium ...
Training en onderzoek voor duurzame oplossingen om de darmgezondheid te ondersteunen en te behouden en verliezen bij monogastrische veestapel te verminderen. KU Leuven
The overall objective of MonoGutHealth is to provide an interdisciplinary, intersectoral and international training experience for ESR’s in an inspiring, novel and highly topical area of livestock research encompassing animal husbandry, social innovations and entrepreneurship. The 11 ESR projects will explore strategies employing nutritional and/or bioactive ingredients to influence perinatal development in monogastrics. The objective being ...
Ontwikkeling, diagnostiek en preventie van gendergerelateerde somatische en mentale comorbiditeiten bij het prikkelbare darm syndroom in Europa KU Leuven
Mental (anxiety and depression) and non-mental (fibromyalgia and chronic fatigue syndrome) comorbidities are highly prevalent in irritable bowel syndrome (IBS), with over 60 million Europeans affected, mostly women, by devastating manifestations, impaired treatment and quality of life. Estimated costs are €43 billion/year for IBS, mostly derived from comorbid IBS. Our hypothesis is that comorbid IBS represents a distinct clinical entity, ...
Super-resolutie genomische mapping voor het microbioom KU Leuven
Animals and bacteria have been working together for about as long as they have co-existed, long before the advent of mankind. The bodies of our ancient ancestors offered protected, nutrient-rich habitats for bacteria. In return, animals could take an evolutionary short-cut to developing new capabilities by ‘borrowing’ bacterial genes. Indeed, when gut bacteria assist with the digestion of e.g. dietary fiber, the resulting metabolites will ...
Validatie van nieuwe immunotherapeutische doelwitten tegen fibrose bij inflammatoire darmziekten KU Leuven
Fibrostenosis is the driving reason for the persistent need in bowel resections in inflammatory bowel diseases (IBD). Current IBD therapies are limited to solely targeting inflammation. While these therapies in some, but not all, cases lead to symptomatic disease remission, recurrent flares interspaced with periods of remission will still result in cumulative gut wall remodeling and fibrosis. Indeed, despite these therapeutic strategies to ...
Kinderen in een juridische taalomgeving. KU Leuven
The ChiLLS research project will investigate the interpreter-mediated questioning of minors who come into contact with the police or with other legal actors in the context of criminal proceedings.
ChiLLS is a continuation of the CO-MINOR-IN/QUEST I and CO-MINOR-IN/QUEST II research projects.
The ChiLLS research project wishes to take the above mentioned research a step further. The researchers will conduct interviews and ...
Bottom-up productie van kunstmatige antitumorale T-cellen KU Leuven
T cells play a central role in anti-tumor immune protection. While their ability to target and eliminate emerging tumor cells is increasingly recognized, fully-established tumors can efficiently evade T cell response. Significant efforts spanning several decades of research have been made to develop T cell-based therapies manufactured from donor-derived T cells. The use of tumor-directed T cells engineered to express chimeric antigen ...