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Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental disorder Universiteit Gent Universiteit Antwerpen
Biallelic variants of the gene encoding for the zinc-finger protein 142 (ZNF142) have recently been associated with intellectual disability (ID), speech impairment, seizures, and movement disorders in nine individuals from five families. In this study, we obtained phenotype and genotype information of 26 further individuals from 16 families. Among the 27 different ZNF142 variants identified in the total of 35 individuals only four were missense. ...
Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders Vrije Universiteit Brussel Universiteit Antwerpen
The GWAS-based association of CACNA1C with bipolar disorder (BPD) is one of the strongest genetic findings to date. CACNA1C belongs to the family of CACN genes encoding voltage-dependent calcium channels (VDCCs). VDCCs are involved in brain circuits and cognitive processes implicated in BPD and schizophrenia (SZ). Recently, it was shown that rare copy number variations (CNVs) are found at an increased frequency in SZ and to a lesser extent ...
Emotional mobility and gender in the court room: the perspective of the consistory courts of Cambrai, Brussels and Tournai Universiteit Gent
Consistory court records show how the rules in canon law regarding entering into marriage were enforced. An examination of the reasons why spouses ran away from their parishes of residence would suggest two major possible fields of research: first, into informal or clandestine marriages; and, second, into marriage impediments, especially those relating to pre-contract and incest. Freedom in the choice of a marriage partner meant that the consent ...