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Severe lactic acidosis in critically ill patients with acute kidney injury treated with renal replacement therapy Universiteit Gent
Characterization of kidney damage using several renal biomarkers in dogs with naturally occurring heatstroke Universiteit Gent
Tolvaptan use in children and adolescents with autosomal dominant polycystic kidney disease: rationale and design of a two-part, randomized, double-blind, placebo-controlled trial KU Leuven
This report describes the rationale and design of a study assessing tolvaptan in children with autosomal dominant polycystic kidney disease (ADPKD). Phase A is a 1-year, randomized, double-blind, placebo-controlled, multicenter trial. Phase B is a 2-year, open-label extension. The target population is at least 60 children aged 12-17 years, diagnosed by family history and/or genetic criteria and the presence of ≥ 10 renal cysts, each ≥ 0.5 cm on ...
Computerized decision support to assess the kidney function in critically ill patients KU Leuven
In critically ill patients, both increased and decreased renal clearance are highly prevalent and may vary during the course of critical illness. Acute kidney injury is a type of organ failure that is highly prevalent in many conditions that cause severe critical illness, and has an association with worse short- and long-term clinical outcomes. Fluctuations in renal clearance will influence the plasma levels and clearance of renally excreted ...
Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease KU Leuven
INTRODUCTION: CKD is associated with alterations of tubular function. Renal gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting, but how and why CKD affects this process and the repercussions of such regulation are unknown. METHODS: We used data on the renal gluconeogenic pathway from more than 200 renal biopsies performed on CKD patients and from 43 kidney allograft patients, and studied three mouse models, of ...
Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality KU Leuven
Acute kidney injury (AKI) is strongly associated with mortality, independently of its cause. The kidney contributes to up to 40% of systemic glucose production by gluconeogenesis during fasting and under stress conditions. Whether kidney gluconeogenesis is impaired during AKI and how this might influence systemic metabolism remain unknown. Here we show that glucose production and lactate clearance are impaired during human and experimental AKI ...
Alkaline phosphatase for treatment of sepsis-induced acute kidney injury Vrije Universiteit Brussel Universiteit Antwerpen
Introduction: To evaluate whether alkaline phosphatase (AP) treatment improves renal function in sepsis-induced acute kidney injury (AKI), a prospective, double-blind, randomized, placebo-controlled study in critically ill patients with severe sepsis or septic shock with evidence of AKI was performed.Methods: Thirty-six adult patients with severe sepsis or septic shock according to Systemic Inflammatory Response Syndrome criteria and renal ...
Population pharmacokinetics of lisinopril in hypertensive children and adolescents with normal to mildly reduced kidney function Universiteit Gent
AimsLisinopril, an angiotensin-converting enzyme inhibitor, is a frequently prescribed antihypertensive drug in the paediatric population, while being used off-label under the age of 6 years in the USA and for all paediatric patients globally. The SAFEPEDRUG project (IWT-130033) investigated lisinopril pharmacokinetics in hypertensive paediatric patients corresponding with the day-to-day clinical population.MethodsThe dose-escalation pilot study ...
Mineral and bone metabolism in male kidney health and disease: role for androgen action? KU Leuven
Androgens play an important role in the development and maintenance of the male reproductive system, the so-called classical target. However, they also have pleiotropic effects on other organs like bone and kidney. Although it is well established that androgen action is essential for normal bone mass accrual and maintenance in men, the contribution of specific AR effects either directly or indirectly mediated by the kidney is not fully ...