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Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis KU Leuven

Davy Vancampfort, Marc De Hert, Martien Wampers
Metabolic syndrome (MetS) and its components are highly predictive of cardiovascular diseases. The primary aim of this systematic review and meta-analysis was to assess the prevalence of MetS and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder, comparing subjects with different disorders and taking into account demographic variables and psychotropic medication use. The ...

Previous disorders and depression outcomes in individuals with 12-month major depressive disorder in the World Mental Health surveys KU Leuven

Ronny Bruffaerts
AIMS: Major depressive disorder (MDD) is characterised by a recurrent course and high comorbidity rates. A lifespan perspective may therefore provide important information regarding health outcomes. The aim of the present study is to examine mental disorders that preceded 12-month MDD diagnosis and the impact of these disorders on depression outcomes. METHODS: Data came from 29 cross-sectional community epidemiological surveys of adults in 27 ...

Group Intervention 'Drop it!' Decreases Repetitive Negative Thinking in Major Depressive Disorder and/or Generalized Anxiety Disorder: A Randomised Controlled Study Vrije Universiteit Brussel Universiteit Gent

Roland Rogiers, Chris Baeken, Dirk Van den Abbeele, Edward R. Watkins, Jonathan Remue, Roos Colman, Rudi De Raedt, Gilbert M. D. Lemmens

Background: Repetitive negative thinking (RNT) is considered to be an important transdiagnostic factor in the onset, course and recurrence of both depressive and anxiety disorders. This study aimed to investigate whether an add-on group intervention ‘Drop it’, compared to treatment as usual, would improve RNT, anxiety and depressive symptoms, as well as quality of life and self-esteem of patients with Major Depressive Disorder (MDD) and/or ...

Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis KU Leuven

Davy Vancampfort, Michel Probst, Marc De Hert
People with severe mental illness (schizophrenia, bipolar disorder or major depressive disorder) die up to 15 years prematurely due to chronic somatic comorbidities. Sedentary behavior and low physical activity are independent yet modifiable risk factors for cardiovascular disease and premature mortality in these people. A comprehensive meta-analysis exploring these risk factors is lacking in this vulnerable population. We conducted a ...

Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis KU Leuven

Davy Vancampfort, Michel Probst, Marc De Hert
Type 2 diabetes mellitus (T2DM) is highly predictive of cardiovascular diseases and can have particularly deleterious health impacts in people with severe mental illness (SMI), i.e. schizophrenia, bipolar disorder or major depressive disorder. This meta-analysis aimed: a) to describe pooled frequencies of T2DM in people with SMI; b) to analyze the influence of demographic, illness and treatment variables as well as T2DM assessment methods; and ...

Action monitoring and depressive symptom reduction in major depressive disorder Universiteit Antwerpen

Didier Schrijvers, Ellen De Bruijn, Yvonne J. Maas, Patrick Vancoillie, Bernard Sabbe
Introduction Action monitoring has been reported to be disturbed in Major Depressive Disorder (MDD). Well-known markers for this action monitoring process are the error negativity/error-related negativity (Ne/ERN) and error positivity (Pe), both event-related potentials (ERP) generated in the anterior cingulate cortex. This study aims to explore the impact of symptom severity reduction on the Ne/ERN and Pe in MDD. Methods Behavioural and ERP ...

Problem behaviours and Major Depressive Disorder in adults with intellectual disability and autism Vrije Universiteit Brussel Universiteit Antwerpen

Linda Baudewijns, Els Ronsse, Valerie Verstraete, Bernard Sabbe, Manuel Morrens, Marco O Bertelli

The high prevalence of Problem Behaviours (PB) in persons with intellectual disability (ID) and Autism Spectrum Disorder (ASD) has been associated by some researchers to a proportionate frequency of Major Depressive Disorder (MDD), which have a different presentation in persons with ID and ASD than in the general population, mostly as behavioural changes. Nevertheless, evidence on this behavioural equivalency is still scarce. The present ...