Development of Radiolabeled PET Tracers for In Vivo Visualization of Phosphodiesterase Type 5 (PDE5) KU Leuven
Phosphodiesterase type 5 (PDE5) is highly expressed in vascular smooth muscle cells, and its inhibition is a primary target for the treatment of erectile dysfunction and pulmonary hypertension. Besides, PDE5 plays a pivotal role in disease progressions such as, cardiac hypertrophy and ventricular remodeling, myocardial ischemia, aortic stenosis, end stage congestive heart failure and atherosclerosis. Several PDE5 inhibitors are approved for ...