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Early maxillary growth in complete cleft lip, alveolus and palate patients following Widmaier-Perko's, or a modified Furlow's technique of soft palate repair Vrije Universiteit Brussel

Maurice Y Mommaerts, Faris Kablan, Shyam Sheth, Zvi Laster

Introduction: The aim was to study the differences in early maxillary growth following the use of two techniques for soft palate repair in complete cleft lip, alveolus and palate patients. Material and methods: Out of sixty-four primary soft palate repairs, two model samples (one of each) having been matched (gender, age, cleft type, maxillary anterior and posterior width at time of soft palate repair) were selected from the groups treated ...

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci Universiteit Antwerpen

Kerstin U. Ludwig, Elisabeth Mangold, Stefan Herms, Bettina Blaumeiser, et al.
We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date. We confirmed associations with all previously identified loci and identified six additional susceptibility regions (1p36, 2p21, 3p11.1, 8q21.3, 13q31.1 and 15q22). Analysis of phenotypic variability identified the first specific genetic risk factor for NSCLP ...

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate Universiteit Antwerpen

Elisabeth Mangold, Kerstin U. Ludwig, Stefanie Birnbaum, Bettina Blaumeiser, Markus Nöthen, et al.
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 × 10−8, relative risk in homozygotes = 1.84, 95% CI 1.342.53) and 10q25.3 (rs7078160, combined P = 1.92 × 10−8, relative risk in homozygotes = ...

Non-Syndromic Cleft Lip with or without Cleft Palate: Genome-Wide Association Study in Europeans Identifies a Suggestive Risk Locus at 16p12.1 and Supports SH3PXD2A as a Clefting Susceptibility Gene KU Leuven

Joris Vermeesch, Koenraad Devriendt, Greet Hens, Carine Carels
Non-syndromic cleft lip with or without cleft palate (nsCL/P) ranks among the most common human congenital malformations, and has a multifactorial background in which both exogenous and genetic risk factors act in concert. The present report describes a genome-wide association study (GWAS) involving a total of 285 nsCL/P patients and 1212 controls from the Netherlands and Belgium. Twenty of the 40 previously reported nsC/LP susceptibility loci ...

Sunitinib Malate plus Lomustine for Patients with Temozolomide-refractory Recurrent Anaplastic or Low-grade Glioma Vrije Universiteit Brussel

Johnny Duerinck, Stephanie Du Four, Wilhelm Sander, Anne-Marie Van Binst, Hendrik Everaert, Alex Michotte, Peter Hau, Bart Neyns

Tyrosine kinase signaling through the vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor- α (PDGFR-α) and KIT cell surface receptors mediates neo-angiogenesis and contributes to cancer cell survival in recurrent anaplastic and low-grade glioma. Thirteen patients with temozolomide-refractory recurrent anaplastic or low-grade glioma were treated with sunitinib malate, a small-molecule tyrosine kinase ...

Identification of an unknown spatial load distribution in a vibrating beam or plate from the final state Universiteit Gent

Karel Van Bockstal
The theoretical and numerical determination of a space-dependent load distribution in a simply supported non-homogeneous Euler-Bernoulli beam and Kirchhoff-Love plate is investigated. The uniqueness of a solution to this inverse source problem is proved, whilst counter examples are constructed to discuss the conditions under which uniqueness holds. A convergent and stable iterative algorithm is proposed for the recovery of the unknown load ...

Cytoreductive nephrectomy and exposure to sunitinib : a post hoc analysis of the immediate surgery or surgery after sunitinib malate in treating patients with metastatic kidney cancer (SURTIME) trial Universiteit Gent

Yasmin AbuU+2010Ghanem, Johannes V. Thienen, Christian Blank, Maureen J. B. Aarts, Michael Jewett, Igle Jan Jong, JeanU+2010Baptiste Lattouf, Harm H. E. Melick, Lori Wood, Peter Mulders, et al.
Objective To analyse if exposure to sunitinib in the Immediate Surgery or Surgery After Sunitinib Malate in Treating Patients With Metastatic Kidney Cancer (SURTIME) trial, which investigated opposite sequences of cytoreductive nephrectomy (CN) and systemic therapy, is associated with the overall survival (OS) benefit observed in the deferred CN arm. Patients and Methods A post hoc analysis of SURTIME trial data. Variables analysed included ...

Self-Esteem and Oral Health-Related Quality of Life within a Cleft Lip and/or Palate Population: A Prospective Cohort Study Universiteit Hasselt KU Leuven

A Aleksieva, G Begnoni, A Verdonck, Annouschka LAENEN, G Willems, MC de Llano-Perula
(1) Objective: To investigate the oral health-related quality of life (OHRQoL) and self-esteem (SE) of a population with cleft lip and/or palate (CLP) and to compare it with a non-affected control cohort. (2) Materials and methods: This study comprised 91 CLP patients and a control group of 790 individuals, seeking orthodontic treatment. OHRQoL and SE were assessed by the Child's Perception Questionnaire (CPQ) and the Dutch adaptation of the ...