Publicaties

The accessibility of the retina with the use of non-invasive and relatively low-cost ophthalmic imaging techniques and analytics provides a unique opportunity to improve the detection, diagnosis and monitoring of systemic diseases. The National Heart, Lung, and Blood Institute conducted a workshop in October 2022 to examine this concept. On the basis of the discussions at that workshop, this Roadmap describes current knowledge gaps and new ...

Generalized transduction is pivotal in bacterial evolution but lacks comprehensive understanding regarding the facilitating features and variations among phages. We addressed this gap by sequencing and comparing the transducing particle content of three different Salmonella Typhimurium phages (i.e. Det7, ES18 and P22) that share a headful packaging mechanism that is typically initiated from a cognate pac site within the phage chromosome. This ...

Many people underestimate the impact ageing can have on their life. Most often those persons only have some of the typical macroscopic characteristics of ageing, such as wrinkles, grey hair, a slower reaction time, and minor functional loss of their sight and/or hearing. Those are, however, the few lucky ones. Indeed, within the greying society, an increasing number of seniors are succumbing to age-related diseases. Many organs are at risk to ...

Congenital heart disease (CHD) comprises a range of structural anomalies, each with a unique natural history, evolving treatment strategies, and distinct long-term consequences. Current prediction models are challenged by generalizability, limited validation, and questionable application to extended follow-up periods. In this JACC Scientific Statement, we tackle the difficulty of risk measurement across the lifespan. We appraise current and ...

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with a five-fold increased stroke risk which can be reduced by 65% with anticoagulation therapy. Detection of AF is hampered by its paroxysmal nature and frequent asymptomatic occurrence. Screening has been suggested to increase AF detection rates and potentially prevent stroke. Targeting screening to the CHA2DS2-VASc risk score can identify individuals who are more ...

In penological literature and in human rights (soft) law, specific groups of people are often categorised as vulnerable based on characteristics, such as age, gender identity, disability, ethnicity, sexual orientation or socio-economic situation. While the concept of vulnerability tends to focus on certain groups of incarcerated persons who are more likely to experience victimisation, it also allows to broaden the scope of victimisation to ...

This Position Statement provides guidelines for health professionals who work with individuals and families seeking predictive genetic testing and laboratory staff conducting the tests. It presents the major practical, psychosocial and ethical considerations associated with presymptomatic and predictive genetic testing in adults who have the capacity to make a decision, children and young people who lack capacity, and adults living with reduced ...