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Opposite effects of one session of 1 Hz rTMS on functional connectivity between pre-supplementary motor area and putamen depending on the dyskinesia state in Parkinson's disease Universiteit Gent Vrije Universiteit Brussel

Anja Flamez, Guo-Rong Wu, Wietse Wiels, Peter Van Schuerbeek, Johan De Mey, Jacques De Keyser, Chris Baeken
Objective: To explore the effects of low-frequency repetitive transcranial magnetic stimulation (LF rTMS) on cortico-striatal-cerebellar resting state functional connectivity in Parkinson's disease (PD), with and without dyskinesias. Methods: Because there is increasing evidence of an involvement of the pre-supplementary motor area (pre-SMA) in the pathophysiology of levodopa induced dyskinesias, we targeted the right pre-SMA with LF rTMS in 17 ...

A single session of rTMS over the left dorsolateral prefrontal cortex influences attentional control in depressed patients Universiteit Gent

Marie-Anne Vanderhasselt, Rudi De Raedt, Chris Baeken, Lemke Leyman, Hugo D'haenen
Depressed patients are impaired in the ability to shift their focus of attention. This attentional control process is related to dysfunctions in the dorsolateral prefrontal cortex (DLPFC). It has been proposed that a dorsal circuit plays an important role in the interaction between emotional and attentional information processing. However, because the different emphasis of fundamental cognitive neuroscience research and clinical research of ...

The effects of high frequency rTMS on negative attentional bias are influenced by baseline state anxiety. Vrije Universiteit Brussel

Chris Baeken, M. Hendricks, Rudi De Raedt, M.a. Vanderhasselt
High frequency (HF) repetitive Transcranial Magnetic Stimulation (rTMS) of the right dorsolateral prefrontal cortex (DLPFC) has been shown to induce an attentional bias towards threatening information in healthy adults, associated with decreased activation in the right DLPFC and increased activation in the right amygdala. Additionally, it has been shown that healthy individuals with higher state anxiety portray similar negative attentional ...

Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression Universiteit Gent Vrije Universiteit Brussel

GuoU+2010Rong Wu, Xiaowan Wang, Chris Baeken
Although in theory sham repetitive transcranial magnetic stimulation (rTMS) has no inherent therapeutic value, nonetheless, such placebo stimulations may have relevant therapeutic effects in clinically depressed patients. On the other hand, antidepressant responses to sham rTMS are quite heterogeneous across individuals and its neural underpinnings have not been explored yet. The current brain imaging study aims to detect baseline neural ...

Accelerated rTMS Vrije Universiteit Brussel Universiteit Gent

Chris Baeken

Three decades of clinical research on repetitive transcranial magnetic stimulation (rTMS) has yielded one clear treatment indication in psychiatry for major depression disorder (MDD). Although the clinical response equals the standard treatment algorithms, the effect sizes on the beneficial outcome remain rather modest. Over the last couple of years, to improve the efficacy in resistant depression, two new avenues have been developed: ...

Bilateral low frequency rTMS of the primary motor cortex may not be a suitable treatment for levodopa-induced dyskinesias in late stage Parkinson's disease Vrije Universiteit Brussel Universiteit Gent

Anja Flamez, Ann Cordenier, Sylvie De Raedt, Veronique Michiels, Sara (89791) Smetcoren, Annick Van Merhaegen-Wieleman, Eva Parys, Jacques De Keyser, Chris Baeken

BACKGROUND: In late stage Parkinson patients there is an unmet need for new treatments to adequately control motor complications, especially dyskinesias. In several preliminary studies, it has been suggested that applying unilateral low-frequency repetitive transcranial magnetic stimulation (LF rTMS), delivered at the primary motor cortex (MC) or the supplementary motor area (SMA), may reduce levodopa-induced dyskinesias (LID), either in a ...