Publicaties
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Heterogeneity of dose distribution in normal tissues in case of radiopharmaceutical therapy with alpha-emitting radionuclides Vrije Universiteit Brussel
Heterogeneity of dose distribution has been shown at different spatial scales in diagnostic nuclear medicine. In cancer treatment using new radiopharmaceuticals with alpha-particle emitters, it has shown an extensive degree of dose heterogeneity affecting both tumour control and toxicity of organs at risk. This review aims to provide an overview of generalized internal dosimetry in nuclear medicine and highlight the need of consideration of the ...
A realistic multiregion mouse kidney dosimetry model to support the preclinical evaluation of potential nephrotoxicity of radiopharmaceutical therapy Vrije Universiteit Brussel
Sub-organ absorbed dose estimates in mouse kidneys are crucial to support preclinical nephrotoxicity analyses of alpha- and beta-particle emitting radioligands exhibiting a heterogeneous activity distribution in kidney. This is however limited by the scarcity of reference dose factors (S values) available in the literature for specific mouse kidney tissues. Methods: A computational multi-region model of a mouse kidney was developed based on ...
Radiation dosimetry to support the preclinical investigation and further development of radiopharmaceutical therapy Vrije Universiteit Brussel
Radiopharmaceutical therapy (RPT) is an exciting and promising field of nuclear medicine which is currently experiencing tremendous progress. The number and variety of novel radioligands being developed and tested in preclinical and clinical settings is growing. As a consequence, the impact of molecular imaging and radiotherapeutics on healthcare is increasingly expanding by addressing unmet clinical needs in the diagnosis and treatment of ...
Consequences of radiopharmaceutical extravasation and therapeutic interventions: a systematic review KU Leuven
PURPOSE: Radiopharmaceutical extravasation can potentially lead to severe soft tissue damage, but little is known about incidence, medical consequences, possible interventions, and effectiveness of these. The aims of this study are to estimate the incidence of extravasation of diagnostic and therapeutic radiopharmaceuticals, to evaluate medical consequences, and to evaluate medical treatment applied subsequently to those incidents. METHODS: A ...
Case Study #3: Antibody Fragments in Radiopharmaceutical Therapy Vrije Universiteit Brussel
Antibodies are widely used as versatile biological tools in cancer therapeutics. In radiopharmaceutical therapy, they have been extensively exploited as vehicles for the delivery of cytotoxic radionuclide payloads for killing tumor cells. However, their success has been impeded by high toxicity profiles due to their long circulatory half-life, which produces high radiation doses to healthy non-target tissues. This issue has prompted the ...
cGMP production of the radiopharmaceutical [F-18]MK-6240 for PET imaging of human neurofibrillary tangles KU Leuven
Fluorine-18-labelled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18 F]MK-6240) is a novel potent and selective positron emission tomography (PET) radiopharmaceutical for detecting human neurofibrillary tangles, which are made up of aggregated tau protein. Herein, we report the fully automated 2-step radiosynthesis of [18 F]MK-6240 using a commercially available radiosynthesis module, GE Healthcare TRACERlab FXFN . ...
Position statement on radiopharmaceutical production for clinical trials KU Leuven
The EU regulation 536/2014 aims to facilitate the experimental use of diagnostic radiopharmaceuticals in particular for GMP requirements and needs to be applied in EU countries. As definitely clarified by this survey, the application is still far from being completed due to national restrictions that are conflicting with the content of the above EU regulation. Although the nuclear medicine centers are obliged to be compliant with national ...
On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion KU Leuven
Radiochemical conversion is an important term to be included in the "Consensus nomenclature rules for radiopharmaceutical chemistry". Radiochemical conversion should be used to define reaction efficiency by measuring the transformation of components in a crude reaction mixture at a given time, whereas radiochemical yield is better suited to define the efficiency of an entire reaction process including, for example, separation, isolation, ...