Application of Semiparametric Mixed Models and Simultaneous Confidence Bands in a Cardiovascular Safety Experiment with Longitudinal Data Universiteit Hasselt KU Leuven
Several pharmacological studies involve experiments aimed at testing for a difference between experimental groups wherein the data are longitudinal in nature, frequently with long sequences per subject. Oftentimes, treatment effect, if present, is not constant over time. In such situations, imposing a parametric mean structure can be too complicated and/or restrictive. A more flexible approach is to model the mean using a semiparametric smooth ...