Publicaties
Current methods for inducing pluripotency in somatic cells Universiteit Gent
Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells KU Leuven
The role of the reprogramming method and pluripotency state in gamete differentiation from patient-specific human pluripotent stem cells Vrije Universiteit Brussel Universiteit Gent
The derivation of gametes from patient-specific pluripotent stem cells may provide new perspectives for genetic parenthood for patients currently facing sterility. We use current data to assess the gamete differentiation potential of patient-specific pluripotent stem cells and to determine which reprogramming strategy holds the greatest promise for future clinical applications. First, we compare the two best established somatic cell ...
A syndrome of short stature, microcephaly and speech delay is associated with duplications reciprocal to the common Sotos syndrome deletion Vrije Universiteit Brussel KU Leuven
Genomic rearrangements are an increasingly recognized mechanism of human phenotypic variation and susceptibility to disease. Sotos syndrome is characterized by overgrowth, macrocephaly, developmental delay and advanced osseous maturation. Haploinsufficiency of NSD1, caused by inactivating point mutations or deletion copy number variants, is the only known cause of Sotos syndrome. A recurrent 2 Mb deletion has been described with variable ...
Cloning in action Universiteit Antwerpen
Analysis of DNA methyltransferases in human oocytes and pre-implantation embryos Vrije Universiteit Brussel
We investigated the spatiotemporal expression pattern of different DNA methyltransferases (DNMTs): DNMT3L, the de novo DNA methyltransferase regulator, and DNMT1, an enzyme responsible for maintenance of the methylation patterns during DNA replication. There are two forms of DNMT1: DNMT1o, found only in oocytes and cleavage stage preimplantation embryos and the somatic form DNMT1s. DNMT1o lacks the N-terminus of DNMT1s. ...