Translational inhibition as novel therapeutic target in neuroblastoma: deciphering the molecular targets and dependencies of silvestrol inhibition (Carolina Nunes) Universiteit Gent
Carolina Nunes
Carolina Nunes
Neuroblastoom (NB) is een agressieve neurale lijst afgeleid kindertijd tumor met slechte overlevingskansen, vooral bij oudere kinderen. Tot nu toe zijn drie bona fide driver oncogene genen geïdentificeerd in neuroblastoom: geamplificeerd in ongeveer de helft van agressieve neuroblastoom gevallen ALK mutaties of amplificaties bij 10% van de gevallen en zeldzame LlN28B amplificaties. Chromosoom 17q gain is veruit de meest voorkomende ...
P. vivax represents a huge burden on the
health, longevity, and socio-economic development of large sections of the
human population. Despite its importance, research on P. vivax lags behind that on P.
falciparum, seriously compromising the development of adequate tools for
its control. Besides less resources available (as compared to P. falciparum), the failure to achieve
continuous culture of P. ...