Publicaties
Botulinum toxin type A treatment in children with cerebral palsy: evaluation of treatment success or failure by means of goal attainment scaling KU Leuven
Nodal oligorecurrent prostate cancer : anatomic pattern of possible treatment failure in relation to elective surgical and radiotherapy treatment templates Universiteit Gent
Heart Failure with Preserved Ejection Fraction: Mechanisms and Treatment Strategies Universiteit Hasselt Vrije Universiteit Brussel
Treatment failure in leishmaniasis Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Two major leishmaniasis treatments have shown a significant decrease in effectiveness in the last few decades, mostly in the Indian subcontinent but also in other endemic areas. Drug resistance of Leishmania correlated only partially to treatment failure (TF) of pentavalent antimonials, and has so far proved not to be important for the increased miltefosine relapse rates observed in the Indian subcontinent. While other patient- or ...
Leishmania antigenuria to predict initial treatment failure and relapse in visceral leishmaniasis/HIV coinfected patients: an exploratory study nested within a clinical trial in Ethiopia Instituut voor Tropische Geneeskunde
Background: Biomarkers predicting the risk of VL treatment failure and relapse in VL/HIV coinfected patients are needed. Nested within a two-site clinical trial in Ethiopia (2011-2015), we conducted an exploratory study to assess whether (1) levels of Leishmania antigenuria measured at VL diagnosis were associated with initial treatment failure and (2) levels of Leishmania antigenuria at the end of treatment (parasitologically-confirmed cure) ...
Validation of a clinical prediction score to target viral load testing in adults with suspected first line treatment failure in resource-constrained settings Instituut voor Tropische Geneeskunde
A clinical prediction score in addition to WHO criteria for anti-retroviral treatment failure in resource-limited settings - experience from Lesotho Instituut voor Tropische Geneeskunde
Drug resistance and treatment failure in leishmaniasis Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factors also contribute to this phenomenon, including the global HIV/AIDS epidemic with its accompanying impact on the immune system. Pentavalent antimonials have been used successfully worldwide for ...
Simplified clinical prediction scores to target viral load testing in adults with suspected first line treatment failure in Phnom Penh, Cambodia Instituut voor Tropische Geneeskunde
BACKGROUND: For settings with limited laboratory capacity, 2013 World Health Organization (WHO) guidelines recommend targeted HIV-1 viral load (VL) testing to identify virological failure. We previously developed and validated a clinical prediction score (CPS) for targeted VL testing, relying on clinical, adherence and laboratory data. While outperforming the WHO failure criteria, it required substantial calculation and review of all previous ...