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Validation of North Sea models: sub report 1. Validation and sensitivity analysis Waterbouwkundig Laboratorium

Kai Chu, Joris Vanlede, Boudewijn Decrop, Frank Mostaert
North Sea models are necessary tools to provide boundary conditions for any model that has its boundaries in the North Sea. They solve the physics of the propagating Kelvin wave in the North Sea (harmonics component) and the wind-driven surge.
This report aims to test 4 different schematisations of the North Sea with regards to their hindcasting performance at calculating water levels in the Belgian Coastal Zone.
• DCSMv5-ZUNOv3
• ...

Development and validation of an automated and marker-free CT-based spatial analysis method (CTSA) for assessment of femoral hip implant migration In vitro accuracy and precision comparable to that of radiostereometric analysis (RSA) Vrije Universiteit Brussel

Thierry Scheerlinck, Mathias Polfliet, Rudi Deklerck, Gert Van Gompel, Nico Buls, Jef Vandemeulebroucke

Background and purpose - We developed a marker-free automated CT-based spatial analysis (CTSA) method to detect stem-bone migration in consecutive CT datasets and assessed the accuracy and precision in vitro. Our aim was to demonstrate that in vitro accuracy and precision of CTSA is comparable to that of radiostereometric analysis (RSA). Material and methods - Stem and bone were segmented in 2 CT datasets and both were registered pairwise. ...

Potential application of digitally linked tuberculosis diagnostics for real-time surveillance of drug-resistant tuberculosis transmission: validation and analysis of test results Instituut voor Tropische Geneeskunde KU Leuven Universiteit Antwerpen

Kamela Charmaine Sy Ng, Conor Meehan, Gabriela Torrea, Leonie Goeminne, Maren Diels, Leen Rigouts, Bouke de Jong, Emmanuel André

Background: Tuberculosis (TB) is the highest-mortality infectious disease in the world and the main cause of death related to antimicrobial resistance, yet its surveillance is still paper-based. Rifampicin-resistant TB (RR-TB) is an urgent public health crisis. The World Health Organization has, since 2010, endorsed a series of rapid diagnostic tests (RDTs) that enable rapid detection of drug-resistant strains and produce large volumes of ...

Translation and validation of Training Needs Analysis Questionnaire among reproductive, maternal and newborn health workers in Tanzania Universiteit Gent

Tumbwene Mwansisya, Columba Mbekenga, Kahabi Isangula, Loveluck Mwasha, Eunice Pallangyo, Grace Edwards, James Orwa, Michaela Mantel, Micheal Mugerwa, Leonard Subi, et al.
Background Continuous professional development (CPD) has been reported to enhance healthcare workers' knowledge and skills, improve retention and recruitment, improve the quality of patient care, and reduce patient mortality. Therefore, validated training needs assessment tools are important to facilitate the design of effective CPD programs. Methods A cross-sectional survey was conducted using self-administered questionnaires. Participants were ...

Analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples from the Flemish measurement network: Optimization and validation of a new CALUX bioassay method Vrije Universiteit Brussel

Kim Croes, Kersten Van Langenhove, Marc Elskens, Marjory Desmedt, Edward Roekens, Alexander Kotz, Michael S. Denison, Willy Baeyens
Since the CALUX (Chemically Activated LUciferase gene eXpression) bioassay is a fast, sensitive and inexpensive tool for the analysis of a high number of samples, validation of new methods is urgently needed. In this study, a new method for the analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples with the CALUX bioassay was developed, optimized and validated. The method consists of 4 steps: filtration, extraction, clean up ...

Copper and tin isotopic analysis of ancient bronzes for archaeological investigation : development and validation of a suitable analytical methodology Universiteit Gent

Eleonora Balliana, Maite Aramendía, Martin Resano, Carlo Barbante, Frank Vanhaecke
Although in many cases Pb isotopic analysis can be relied on for provenance determination of ancient bronzes, sometimes the use of "non-traditional" isotopic systems, such as those of Cu and Sn, is required. The work reported on in this paper aimed at revising the methodology for Cu and Sn isotope ratio measurements in archaeological bronzes via optimization of the analytical procedures in terms of sample pre-treatment, measurement protocol, ...

High-resolution Orbitrap mass spectrometry for the analysis of carotenoids in tomato fruit: validation and comparative evaluation towards UV-VIS and tandem mass spectrometry Universiteit Gent

Lieven Van Meulebroek, Julie Vanden Bussche, Kathy Steppe, Lynn Vanhaecke
In this study, a generic extraction protocol and full-scan high-resolution Orbitrap-MS detection method were developed, enabling the metabolomic screening for carotenoids in tomato fruit tissue. To this end, the carotenoids lutein, zeaxanthin, α-carotene, β-carotene and lycopene (representing both xanthofylls and carotenes) were considered. The extraction procedure was optimized by means of a D-optimal design and consisted of a liquid-liquid ...

Prediction of mechanical properties of knitted fabrics under tensile and shear loading : mesoscale analysis using representative unit cells and its validation Universiteit Gent

Tien Dung Dinh, Oliver Weeger, Sawako Kaijima, Sai-Kit Yeung
This article presents a numerical framework to predict the mechanical behavior of knitted fabrics from their discrete structure at the fabric yarn level, i.e., the mesostructure, utilizing the hierarchical multiscale method. Due to the regular distribution of yarn loops in a knitted structure, the homogenization theory for periodic materials can be employed. Thus, instead of considering the whole fabric sample under loading, a significantly less ...

Validation of a simple and robust multi-residue gas chromatography-mass spectrometry method for the analysis of polycyclic aromatic hydrocarbons, phthalates and biocides in roofing material leachate and roof runoff Universiteit Gent

Pieter-Jan De Buyck, Jonas Couvent, Yannick Verheust, Stijn Van Hulle, Diederik Rousseau, Ann Dumoulin
A multi-residue method for the determination of 16 polycyclic aromatic hydrocarbons (PAHs), biocides diuron (DIU), octylisothiazolinone (OIT) and mecoprop (MCPP), and phthalates bis(2-ethylhexyl) phthalate (DEHP) and diisodecyl phthalate (DIDP) in material leachate and roof runoff is presented. The method aims to keep sample pretreatment as simple as possible, not only to minimize sample contamination and sample losses, but also to have an ...

Development and validation of a sensitive ultra performance liquid chromatography tandem mass spectrometry method for the analysis of fentanyl and its major metabolite norfentanyl in urine and whole blood in forensic context KU Leuven

Ruth Verplaetse, Jan Tytgat
Fentanyl and its major metabolite norfentanyl often occur in low doses in biological samples. Therefore, a highly sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and fully validated. Sample preparation was performed on a mixed-mode cation exchange solid phase extraction (SPE) cartridge with an additional alkaline wash step to decrease matrix effects and thus increase sensitivity. Ionization of ...