Tomographic evaluation of tracer distribution (PET, SPECT). - Medical Imaging: acquition, reconstruction PET and SPECT. - Metabolic Imaging in acute and chronic heart disease. - Metabolic Imaging in oncology and inflammation - Neuroactivation, protein deposit and receptor studies of the brain. - Radio immunotherapy. - Molecular imaging - Brain imaging. - Image registration (PET, SPECT, MRI, CT).
The In Vivo Cellular and Molecular Imaging (ICMI) Core Facility is specialized in nuclear and optical imaging of small animals. The lab is equipped with a myriad of multi-modality cameras and ex vivo analysis techniques to study tracer biodistribution, pharmacokinetics, dosimetry, and therapeutic efficacy of radiopharmaceuticals. The lab is situated in a biosafety level 2 environment with direct access to the animalarium.
Fundamental properties of the electronic excited state and of the use of this basic knowledge in different physical and physicochemical problems . - Intra- and intermolecular interactions in the electronic excited state. - Photochemistry and photophysics of ordered systems such as micelles, inverse micelles and membranes. Stabilization of ordered systems through polymerization. - Adsorption of organic molecules at surfaces and the influence ...
The department of 'Imaging and Physical Sciences' consists of the subunits Radiology and Clinical Imaging (RADI), 'Radiotherapy' (KANK), 'Nuclear Medicine' (NUGE). The main research topics for these three subunits are: For Radiology and Clinical Imaging: 1. Diffusion and perfusion magnetic resonance (MR) imaging and their application to the characterisation of healthy and pathologic tissues; 2. Susceptibility MR imaging of trabecular bone and ...
Our research is aimed at better understanding of the VWF/ADAMTS13/platelet axis in hemostatic, thrombotic and inflammatory processes. We use various in vivo models, combined with intravital microscopy to study molecular and cellular interactions. In particular, we focus on designing novel therapeutic strategies that interfere with von Willebrand factor function for treatment of thrombo-inflammatory disease.
Research activities in the group of "Theoretical Chemistry and Molecular Modelling" aim at linking domains of relevance in physical chemistry, chemical physics, and material research, such as:
- polymer physics and surfaces;
- electron structure theory of neutral and ionized molecules (anions, cations), clusters or radicals;
- advanced ionization spectroscopy (photoelectron spectroscopies [XPS, UPS, Synchrotron], Electron ...
Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.