Assesment of the impact of a non-invasive clinical decision support tool for antibiotic allergy label delabeling and refinement (ALLERGY)

Our final goal is to initiate a more proactive antibiotic allergy delabeling strategy in Belgium, instead of the ‘urgency’-driven approach that is mostly performed in clinical practice nowadays (i.e., when patients are in high need of the respective antibiotic (class), or are triggered to investigate their antibiotic allergy label due to, e.g., a perceived reaction or upcoming surgery). Currently, the standard approach is invasive skin and provocation testing, traditionally delivered by allergists, mostly targeting only those patients with the highest benefit-risk, because of time- and resources constraints.
However, an optimized non-invasive approach will make delabeling more assessable to non-allergists, and can cover a much broader patient population, i.e., eventually all patients with an antibiotic allergy label, without any consumable cost. Therefore, we suggest implementation of our non-invasive delabeling tool as a standard first step before antibiotic prescription in patients with an antibiotic allergy label, and eventually, retrospective use of the tool in all electronic patient record systems.
Hereby we contribute to the safe and more rational use of antibiotics.