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Organisation
Research Group Molecular Neurobiology (VIB-KU Leuven)
Division
Main organisation:Department of Neurosciences
Lifecycle:1 Jan 2017 → Today
Organisation profile:
Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.
Keywords:Neurobiology
Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing, Laboratory medicine
Sub-organisation(s)
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- Laboratory of Interneuron Developmental Dynamics (VIB-KU Leuven)
- Laboratory of Sleep and Synaptic Plasticity (VIB-KU Leuven)
- Laboratory of Proteolytic Mechanisms in Neurodegeneration (VIB-KU Leuven)
- Laboratory of Neuronal Communication (VIB-KU Leuven)
- Laboratory of Neuronal Differentiation (VIB-KU Leuven Center for Brain & Disease Research)
- Laboratory of Emotional Circuit Development (VIB-KU Leuven)
- Laboratory of Membrane Trafficking (VIB-KU Leuven)
- Laboratory of Stem Cell and Developmental Neurobiology (VIB-KU Leuven)
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven)
- Laboratory of Glia Biology (VIB-KU Leuven)
Current researchers
1 - 7 of 7 results
- Patrik Verstreken (Responsible)
- Natalia Gunko (Member)
- Véronique Hendrickx (Member)
- Esther Klingler (Member)
- Sebastian Munck (Member)
- Nicolas Peredo (Member)
- Angéle Pouwels (Member)
Projects
1 - 10 of 22
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Flanders BioImaging: Leading Imaging Application Integrated Service and Enablement (FBI-LIAISE)From1 Jan 2023 → TodayFunding: FWO International research infrastructure (IRI)
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- FB-III (“FB triple-I”) : Flanders BioImaging: Integrating Imaging Infrastructure from cell to man.From1 Feb 2021 → TodayFunding: FWO International research infrastructure (IRI)
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Development of new chemical tools to investigate the role of L-type calcium channels in diseases.From6 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → 30 Sep 2023Funding: BOF - projects
- Structural bases of γ-secretase processivity in Familial Alzheimer's DiseaseFrom1 Feb 2019 → 1 Feb 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 168
- Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons(2011)
Authors: Laura Trovo, Carlos Dotti
Pages: 933 - 943 - HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory(2012)
Authors: III Sando, Natalia Gunko, Simon Pieraut, Lujian Liao, III Yates, Anton Maximov
Pages: 821 - 834 - Pyramidal neuron polarity axis is defined at the bipolar stage(2008)
Authors: Carlos Dotti
Pages: 178 - 185 - The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments(2008)
Authors: Carlos Dotti
Pages: 384 - 392 - Oxidative stress activates the pro-survival TrkA pathway through membrane cholesterol loss(2011)
Authors: Francesca Iannilli, Carlos Dotti
Pages: 1033 - 1042 - A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR(2010)
Authors: Carlos Dotti
Pages: 4074 - 4086 - Neu3 Sialidase-Mediated Ganglioside Conversion Is Necessary for Axon Regeneration and Is Blocked in CNS Axons(2014)
Authors: Carlos Dotti
Pages: 2477 - 2492 - Glutamatergic Synapse Formation is Promoted by alpha 7-Containing Nicotinic Acetylcholine Receptors(2012)
Authors: Natalia Gunko
Pages: 7651 - 7661 - The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides
Authors: Carlos Dotti
- Distinct temporal hierarchies in membrane and cytoskeleton dynamics precede the morphological polarization of developing neurons(2014)
Authors: Annette Gärtner, Carlos Dotti
Pages: 4409 - 19