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Researcher
Chris Ulens
- Disciplines:Neurosciences not elsewhere classified, Electrophysiology, Pharmacology not elsewhere classified, Structural biology, Molecular biophysics, Other basic sciences not elsewhere classified
Affiliations
- Laboratory of Structural Neurobiology (Division)
Responsible
From1 Jan 2012 → Today - Laboratory of Structural Neurobiology (Division)
Member
From1 Oct 2007 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → 31 Jan 2004
Projects
1 - 10 of 34
- Rationally designed, antibody-like proteins as therapeutics against short-chain α-neurotoxins in venomous snakebite.From1 Oct 2025 → TodayFunding: IOF - technology validation in lab
- Acquisition of a cryo-holder for an existing JEOL F200 electron microscope to enable structural biology applications in the context of human diseaseFrom1 Jan 2025 → TodayFunding: BOF - scientific equipment program
- Acquisition of a cryo-holder for an existing JEOL F200 electron microscope to enable structural biology applications in the context of human diseaseFrom1 Jan 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structural and pharmacological characterization of the insect γ-aminobutyric acid receptor, Resistance to Dieldrin (RDL)From1 Oct 2024 → 30 Sep 2025Funding: BOF - postdoctoral mandates
- Structural and functional characterisation of the Myzus persicae nicotinic acetylcholine receptors for the development of safer agricultural pesticidesFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Molecular mechanism of insect pentameric ligand-gated ion channels as a target for new insecticidesFrom1 Oct 2023 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Molecular structure and function of an insect pH-sensitive chloride (pHCl) channel, a target for safer insecticides.From1 Oct 2023 → TodayFunding: FWO fellowships
- Development of nanobodies as a strategy to neutralize neurotoxins in envenomation by poisonous snakebites.From12 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- A broad-spectrum antidote against venomous snakebites based on engineering of nicotinic acetylcholine receptors and derivatives.From1 Nov 2021 → 1 Jun 2024Funding: FWO junior postdoctoral fellowship
Publications
1 - 10 of 48
- Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan(2024)Published in: StructureISSN: 0969-2126Issue: 11Volume: 32
- Acetylcholine-Binding Protein Affinity Profiling of Neurotoxins in Snake Venoms with Parallel Toxin Identification(2023)Published in: International Journal of Molecular SciencesISSN: 1661-6596Issue: 23Volume: 24
- An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules(2023)Published in: Biochemical PharmacologyISSN: 0006-2952Volume: 216
- Pentameric ion channels as targets for drug discovery in human disease(2023)
- Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor(2023)Published in: ElifeISSN: 2050-084XVolume: 12
- High-Throughput Venomics(2023)Published in: Journal of Proteome ResearchISSN: 1535-3893Issue: 6Volume: 22Pages: 1734 - 1746
- Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium(2022)Published in: Biochimica et Biophysica Acta. BiomembranesISSN: 0005-2736Issue: 10Volume: 1864
- The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors(2022)Published in: Nature CommunicationsISSN: 2041-1723Issue: 1Volume: 13
- Spicy Science: Structural snapshots of a polymodal nociceptor reveal insights on our sensation to pain, heat, and taste(2022)Published in: Cell CalciumISSN: 0143-4160Volume: 102
- Clinical and molecular characteristics of a novel rare de novo variant in PPP2CA in a patient with a developmental disorder, autism, and epilepsy.(2022)Published in: Frontiers in Cell and Developmental BiologyISSN: 2296-634XVolume: 10