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Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
Main organisation:Department of Human Genetics
Lifecycle:1 Jan 2012 → Today
Organisation profile:
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Keywords:genetics
Disciplines:Morphological sciences, Oncology
Current researchers
1 - 10 of 14 results
- Diether Lambrechts (Responsible)
- Ahmad Ata Ahmad Abuhani (Member)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Chen Gu (Member)
- Aurelie Mechels (Member)
- Heesoo Song (Member)
- Pierre Van Mol (Member)
Projects
1 - 10 of 83
- Exploring Tumor Antigen Landscape during checkpoint immunotherapyFrom13 Oct 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A Phase 2 clinical study to assess efficacy of induction carboplatin/paclitaxel + pembrolizumab for locoregionally advanced penile cancer: PRIAMFrom22 Aug 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development and clinical validation of a personalized mRNA-based cancer vaccine for patients with advanced hepatocellular carcinomaFrom1 Jan 2025 → TodayFunding: Foundations, funds and other with scientific goal
- Homologous recombination deficiency (HRD) testing on liquid biopsies in ovarian cancerFrom1 Jan 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Advancing Penile, Vulvar and Urethral Squamous Cell Carcinoma management by identifying tissue and blood-based signals for immunochemotherapy response.From1 Jan 2025 → TodayFunding: Foundations, funds and other with scientific goal
- Deciphering the tumor antigen landscape of CD4+ T-cells during checkpoint immunotherapyFrom1 Jan 2025 → TodayFunding: Foundations, funds and other with scientific goal
- Analysis of the immune response in cancer patients treated with immune checkpoint blockade therapies, focusing on the antigenic landscape recognized by expanding tumorinfiltrating T cells in lung cancer patientsFrom15 Nov 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Spatial and single-cell RNA sequencing Transcriptomics Reveal the Heterogeneous Landscape and Microenvironment of Primary Urethral Squamous Cell CarcinomaFrom11 Oct 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Advanced image analysis to predict response to immune check point blockade in breast cancer (ref. BAP-2023-787).From4 Jun 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 681
- Lessons from the adjuvant bevacizumab trial on colon cancer: what next?(2011)Published in: JOURNAL OF CLINICAL ONCOLOGYISSN: 0732-183XIssue: 1Volume: 29Pages: 1 - 4
- Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium(2015)Published in: British Journal of CancerISSN: 0007-0920Issue: 5Volume: 113Pages: 817 - 26
- Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer(2015)Published in: Nature GeneticsISSN: 1061-4036Issue: 4Volume: 47Pages: 373 - 80
- Successful application of endoscopic ultrasound-guided fine needle biopsy to establish pancreatic patient-derived tumor xenografts: a pilot study(2016)Published in: EndoscopyISSN: 0013-726XIssue: 11Volume: 48Pages: 1016 - 1022
- Lung Aeration in COVID-19 Pneumonia by Ultrasonography and Computed Tomography(2022)Published in: Journal of Clinical MedicineISSN: 2077-0383Issue: 10Volume: 11
- Common variants in breast cancer risk loci predispose to distinct tumor subtypes(2022)Published in: Breast Cancer ResISSN: 1465-5411Issue: 1Volume: 24
- Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel(2023)Published in: Journal of medical geneticsISSN: 0022-2593Issue: 12Volume: 60Pages: 1186 - 1197
- Improved metabolite identification with MIDAS and MAGMa through MS/MS spectral dataset-driven parameter optimization(2016)Published in: MetabolomicsISSN: 1573-3882Issue: 6Volume: 12Pages: 1 - 16
- Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration(2016)Published in: OncotargetISSN: 1949-2553Issue: 45Volume: 7Pages: 72381 - 72394
- Genetic Markers in Relation to Bevacizumab-induced Hypertension(2011)Published in: EUROPEAN JOURNAL OF CANCERISSN: 0959-8049Issue: 3Volume: 47Pages: 685 - 694