Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Current researchers
1 - 7 of 7 results
- Max Mazzone (Responsible)
- Emanuele Berardi (Member)
- Marie-Pauline Orban (Member)
- Carla Riera Domingo (Member)
- Silvia Rivis (Member)
- Tommaso Scolaro (Member)
- Shikang Zhao (Member)
Projects
1 - 10 of 68
- Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancerFrom5 Mar 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistanceFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancerFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the CDA/P2Y6 axis to overcome immunosuppression and favor response to immune checkpoint inhibitors in pancreatic cancerFrom1 Jul 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Tackling tumor immunosuppression by reprograming eicosanoid metabolism and signaling in the tumor microenvironmentFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Tackling SLC1A3 in tumor-associated macrophages to overcome anti-PD1 immunotherapy resistance in breast cancerFrom31 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- LipoMacs: functional Lipidomics to unlock Macrophage-mediated therapyFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research (SBO)
- BD Imaging Cell Sorter – BD Cell View TechnologyTMFrom24 Jun 2022 → TodayFunding: Other federal scientific institutions
- Tricking tumor immunosuppression: RNA epigenetics as novel target to improve cancer immunotherapyFrom1 Jan 2022 → TodayFunding: FWO EOS
- Duchenne muscular dystrophy.From1 Jan 2022 → 31 Dec 2022Funding: Nonprofit institution or equivalents
Publications
1 - 10 of 314
- Expression of Glypican 3 Is an Independent Prognostic Biomarker in Primary Gastro-Esophageal Adenocarcinoma and Corresponding Serum Exosomes(2019)
Authors: Mohammad Rahbari, Mathieu Pecqueux, Daniela Aust, Holger Stephan, Oliver Tiebel, Antonios Chatzigeorgiou, Torsten Tonn, Franziska Baenke, Venkatesh Rao, Nicole Ziegler, et al.
- ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation(2018)
Authors: Elisenda Alsina-Sanchis, Yaiza Garcia-Ibanez, Ana M Figueiredo, Carla Riera Domingo, Agnes Figueras, Xavier Matias-Guiu, Oriol Casanovas, Luisa M Botella, Miquel A Pujana, Antoni Riera-Mestre, et al.
Pages: 1216 - 1229 - Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo(2019)
Authors: Catarina Oliveira, Sara Granja, Nuno M Neves, Rui L Reis, Fatima Baltazar, Tiago H Silva, Albino Martins
- PHD2 Constrains Antitumor CD8+T-cell Activity(2023)
Authors: Max Mazzone
Pages: 339 - 350 - FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis(2016)
Authors: Len Verbeke, Olivier Govaere, Ricard Farré Marti, Mathias Wenes, Max Mazzone, Frederik Nevens, Wim Laleman
- PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner(2017)
Authors: Qinghui Zhang, Max Mazzone
Pages: 2836 - 2844 - Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis(2019)
Authors: Max Mazzone, Gabriele Bergers
Pages: 535 - 560 - Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium(2017)
Authors: Shehab Ismail Mohamed, Max Mazzone
Pages: 2373 - 2389 - MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability(2017)
Authors: Max Mazzone
Pages: 55 - Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis(2011)
Authors: Veronica Finisguerra, Sofie Deschoemaeker, Mathias Wenes, Alexander Hamm, Max Mazzone
Pages: 122