Exploring novel approaches to gas chromatography for pharmaceutical analysis

The project focuses on exploring novel approaches and methodologies in gas chromatography (GC) for pharmaceutical analysis. Key aspects include investigating and implementing alternative detection techniques for GC, such as vacuum ultraviolet (VUV) spectroscopy for residual solvent and water analysis. Additionally, the project aims to utilize mass spectrometry with a high-efficiency source (HES) and cryogenic trapping system (CTS) for trace-level analysis of drug candidates, including genotoxic impurities and nitrosamine precursors. An equally significant goal is the development of a computer-organized screening and method optimization system for GC. This system aims to automate the method development process for pharmaceutical samples, streamlining decision-making and reducing the time and trial-and-error typically required to establish robust and reliable GC methods for commercial release.