Next-generation brain interface technology: Refinement and validation of a bi-directional, three dimensional, neural probe for deep brain stimulation therapy

Deep brain stimulation (DBS) is a treatment for a brain diseases that delivers electrical stimulation via implanted electrodes to regulate neural activity. However, DBS success is hampered by poor stimulation precision and open-loop (or very limited closed-loop) modes which do not adapt to brain state. We have developed a novel three-dimensional, bi-directional brain interface technology that enables unprecedented precision for recording and stimulation at the cellular level, in a closed-loop mode. Our 3D neural probe can disrupt current DBS technology by offering safe therapy, tailored to individual patients, their unique brain anatomy and symptoms. We have significant in-vivo data demonstrating reduced mechanical damage, efficient 3D deployment, and real time spike sorting. Moreover, simulations confirm high selectivity, allowing recording and stimulation of single cells with resolutions 10x superior to probes such as Neuropixels. In this project, will use rodent models and simulations to further refine, validate and benched mark the 3D neural probe againsts existing gold standards. We will then use it to treat Parkinson’s disease in a rodent model and compare effectiveness to current standards. Finally, we will initiate patient translation by evaluating the probe’s performance in resected human brain. Future translation of the 3D neural probe will enable the next-generation of brain interface technology to offer safe, individualized, precision brain stimulation therapy.

Keywords:Brain Stimulation, Electrophysiology

Disciplines:Neurophysiology

Project type:PhD project