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Researcher
Alfons Verbruggen
- Disciplines:Medicinal products, Biomarker discovery and evaluation, Drug discovery and development, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Faculty of Pharmaceutical Sciences (Faculty)
Member
From1 Oct 2020 → Today - Radiopharmaceutical Research (Division)
Member
From1 Oct 1999 → 30 Sep 2019
Projects
1 - 10 of 10
- Oncocidia_the novel anticancer therapy: phase 0 clinical study.From1 Jan 2013 → 31 Dec 2013Funding: IOF - Industrial Research Fund
- translational study of the modulation of fosfodiesterase type 10A expression by dopaminergic neurotransmission using molecular imagingFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Development and evaluation of PET ligands for the in vivo visualisation of phosphodiesterase type 5 (PDE5).From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Synthesis and biological evaluation of carbon-11 and fluorine-18 labelled P2X7-receptor ligands for diagnosis of neurological diseases using positron emission tomographyFrom1 Oct 2011 → 30 Sep 2015Funding: FWO fellowships
- In vivo molecular imaging research (IMIR).From1 Nov 2010 → 31 Oct 2018Funding: BOF - Concerted Research Project from 1994
- Molecular and functional imaging as a pivotal tool for translational medicine in the field of neuroscience and oncology: a platform creating a bridge between basic research, clinical development and industrial application.From1 Oct 2010 → 30 Sep 2014Funding: IOF - Industrial Research Fund
- Preclinical validation and first in man study of PET radioligands for the cannabinoidreceptor type 2.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project (including WEAVE projects)
- Synthesis and (pre)clinical evaluation of PET radioligands for in vivo visualization of phosphodiesterase 10, an enzyme involved in neurological and psychiatric disorders.From1 Oct 2009 → 30 Sep 2010Funding: BOF - Other initiatives
- Development of a radiolabelled probes for the in vivo visualisation of the TRPV1 receptor with PETFrom1 Oct 2008 → 24 Jan 2013Funding: IWT personal funding - strategic basic research grants
- Anti-kanker therapie versterkt door kleine radioactief gelabelde compounds met affiniteit voor necrosis (sRALNAC): een Prrof-of-Principle experiment ter ondersteuning van een nieuw patent aanvraag.From1 Jul 2008 → 30 Jun 2009Funding: IOF - Industrial Research Fund
Publications
1 - 10 of 117
- Impurity profiling of N,N′-ethylenebis-L-cysteine diethyl ester (Bicisate)(2018)Published in: Journal of Pharmaceutical and Biomedical AnalysisISSN: 0731-7085Volume: 150Pages: 132 - 136
- Pretargeted PET Imaging Using a Bioorthogonal 18F‑Labeled trans- Cyclooctene in an Ovarian Carcinoma Model(2017)Published in: Bioconjugate ChemistryISSN: 1043-1802Issue: 12Volume: 28Pages: 2915 - 2920
- (AlF)-F-18-Labeling Of Heat-Sensitive Biomolecules for Positron Emission Tomography Imaging(2017)Published in: TheranosticsISSN: 1838-7640Issue: 11Volume: 7Pages: 2924 - 2939
- Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging(2017)Published in: JOURNAL OF NUCLEAR MEDICINEISSN: 0161-5505Issue: 6Volume: 58Pages: 975 - 981
- Carbon-11 and Fluorine-18 Radiolabeled Pyridopyrazinone Derivatives for Positron Emission Tomography (PET) Imaging of Phosphodiesterase-5 (PDE5)(2017)Published in: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 1Volume: 60Pages: 486 - 496
- Micro-Flow Photosynthesis of New Dienophiles for Inverse-Electron-Demand Diels-Alder Reactions. Potential applications for pretargeted in vivo PET imaging(2017)Published in: Chemical ScienceISSN: 2041-6520Issue: 2Volume: 8Pages: 1251 - 1258
- What we observe in vivo is not always what we see in vitro: Development and Validation of C-JNJ-42491293, A novel radioligand for mGluR2(2017)Published in: JOURNAL OF NUCLEAR MEDICINEISSN: 0161-5505Issue: 1Volume: 58Pages: 110 - 116
- Synthesis and preclinical evaluation of [C-11]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL)(2017)Published in: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 136Pages: 104 - 113
- [18F]JNJ42259152 binding to phosphodiesterase 10A, a key regulator of medium spiny neuron excitability, is altered in the presence of cyclic AMP(2016)Published in: JOURNAL OF NEUROCHEMISTRYISSN: 0022-3042Issue: 5Volume: 139Pages: 897 - 906
- Development and evaluation of tau PET ligands(2016)