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Researcher
Dirk Jochmans
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Sep 2010 → Today
Projects
1 - 5 of 5
- Prohylaxis of at risks persons with an ultrapotent SARS-CoV-2 neutralizing antibody.From20 May 2020 → 21 May 2021Funding: FWO thematic call for applied research
- Optimize viral replication in primary human airway epithelial (HAE) cells for use in antiviral research to combat respiratory viral infectionsFrom22 Sep 2019 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Organoids for Virus Research - An innovative training-ETN programmeFrom1 Jan 2019 → 31 Dec 2022Funding: H2020-EU.1.3.- EXCELLEN SCIENCE - Marie Skłodowska-Curie actions
- Development and mechanism of action of novel inhibitors of rabies virus replication.From17 Sep 2018 → 27 Mar 2025Funding: Own budget, for example: patrimony, inscription fees, gifts
- Towards a combined post-exposure prophylaxis and successful treatment of rabies in humansFrom1 Oct 2017 → 30 Sep 2020Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 114
- Antiviral activities of phenylalanine derivatives carrying carboxylic acid bioisosteres against chikungunya and parainfluenza virus type 3.(2025)Published in: Bioorganic & Medicinal ChemistryISSN: 0968-0896Volume: 130Pages: 118343
- Identification and Exploration of a Series of SARS-Cov-2 MPro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group(2025)Published in: ACS Medicinal Chemistry LettersISSN: 1948-5875Issue: 10Volume: 16
- Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor(2025)Published in: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 13Volume: 68Pages: 13436 - 13454
- A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein(2025)Published in: NatureISSN: 0028-0836Issue: 8058Volume: 640
- A coronavirus assembly inhibitor that targets the viral membrane protein(2025)Published in: NatureISSN: 0028-0836Issue: 8058Volume: 640
- Towards novel strategies for post-exposure prophylaxis and treatment of rabies(2025)
- The Combination of GS-441524 (Remdesivir) and Ribavirin Results in a Potent Antiviral Effect Against Human Parainfluenza Virus 3 Infection in Human Airway Epithelial Cell Cultures and in a Mouse Infection Model(2025)Published in: VirusesISSN: 1999-4915Issue: 2Volume: 17
- Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease(2025)Published in: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 3Volume: 68Pages: 2920 - 2941
- Optimization of SARS-CoV-2 Mpro Inhibitors by a Structure-Based Multilevel Virtual Screening Method(2025)Published in: International Journal of Molecular SciencesISSN: 1661-6596Issue: 2Volume: 26
- The effects of Remdesivir's functional groups on its antiviral potency and resistance against the SARS-CoV-2 polymerase(2024)Published in: Antiviral ResISSN: 0166-3542Volume: 232
Patents
1 - 5 of 5
- Design synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
- Antiviral compounds
- Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
- Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
- Design synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity