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Researcher
Aernout Luttun
- Disciplines:Vascular diseases, Cardiac and vascular medicine not elsewhere classified, Stem cell biology, Cell therapy
Affiliations
- Centre for Molecular and Vascular Biology (Division)
Member
From1 Jan 2002 → Today
Projects
1 - 10 of 38
- Unraveling the role of transcription factors Prdm16 and Zeb2 in the pathogenesis of idiopathic pulmonary fibrosisFrom26 Aug 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Identifying druggable targets downstream of atheroprotective factor PRDM16 for treatment of ischemic diseaseFrom1 Mar 2025 → TodayFunding: Other federal public and semi-governmental institutions
- Is the cerebroprotective function of Prdm16 during ischaemic stroke mediated by controlling the TGFbeta/BMP signalling balance?From1 Oct 2024 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Unravelling the role of transcription factor Prdm16 in endothelial cells during the progression of ischaemic stroke.From1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Human Stem Cell-Derived Cardiac Models to Investigate Intercellular Dynamics in Epicardial Activation and Cardiac RemodelingFrom1 Oct 2023 → TodayFunding: FWO fellowships
- The role of transcription factor PRDM16 in the pathogenesis of pulmonary arterial hypertensionFrom1 Sep 2023 → TodayFunding: FWO fellowships
- Unraveling the cellular landscape and (epi)genetic mechanisms at single-cell resolution and the effect of Prdm16 deficiency during the pathogenesis of pulmonary arterial hypertensionFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Next-generation, multi-technology immune-monitoring and easy-access spectral flow cytometryFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Study of the cellular and molecular mechanisms underlying cardiomyopathy caused by transcription factor PR domain containing 16 (Prdm16) deficiency in cardiomyocytes and non-cardiomyocyte cell typesFrom1 Apr 2022 → 1 Dec 2023Funding: Other federal public and semi-governmental institutions
- Unraveling the role of transcription factor Prdm16 in regulating the cellular and (epi)genetic landscape of atherosclerosis at single-cell resolutionFrom21 Aug 2021 → TodayFunding: FWO fellowships
Publications
1 - 10 of 72
- Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease(2025)Published in: Scientific ReportsISSN: 2045-2322Issue: 1Volume: 15
- PRDM16, a new kid on the block in cardiovascular health and disease(2025)Published in: CARDIOVASCULAR RESEARCHISSN: 0008-6363Issue: 8Volume: 121Pages: 1156 - 1172
- Exploring and exploiting the role of PRDM16 in cardiac development and function using a multi-disciplinary approach in mice and zebrafish(2024)
- Smad1/5 is acetylated in the dorsal aortae of the mouse embryo before the onset of blood flow, driving early arterial gene expression(2024)Published in: CARDIOVASCULAR RESEARCHISSN: 0008-6363Issue: 16Volume: 120Pages: 2078 - 2091
- PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates(2024)Published in: Life Sci AllianceISSN: 2575-1077Issue: 12Volume: 7
- Differential roles of BMP-SMAD1/5 signalling in lymphatic collecting vessels and capillaries(2024)
- Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction(2024)Published in: Eur Heart J OpenISSN: 2752-4191Issue: 1Volume: 4
- Unraveling the determinants of liver sinusoidal endothelial cell features during health and disease - The context-dependent role of ZEB2(2023)
- Arteriovenous Fistulae in Chronic Kidney Disease and the Heart: Physiological, Histological, and Transcriptomic Characterization of a Novel Rat Model(2022)Published in: Journal of the American Heart Association. Cardiovascular and Cerebrovascular DiseaseISSN: 2047-9980Issue: 20Volume: 11
- Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model(2022)Published in: Cellular and Molecular Life SciencesISSN: 1420-682XIssue: 6Volume: 79