< Back to previous page
Researcher
Bruno De Geest
- Keywords:immunology, polymer chemistry, Nanomedicine
- Disciplines:Biopharmaceutics, Adaptive immunology, Cancer therapy, Innate immunity, Synthesis of materials, Chemistry of clusters, colloids and nanomaterials, Macromolecular and materials chemistry not elsewhere classified, Animal immunology, Vaccines, Vaccinology
Affiliations
- Department of Pharmaceutics (Department)
Member
From1 Oct 2003 → Today
Projects
1 - 10 of 72
- High quality characterization of extracellular vesicles by nanoparticle tracking analysisFrom1 Dec 2025 → TodayFunding: BOF - scientific equipment program
- NanoClaws as a cure for feline immunodeficiency virus (FIV): constructing CD134-targeting CRISPR-Cas9 nanoparticles against FIVFrom1 Nov 2025 → TodayFunding: FWO Strategic Basic Research Grant
- Tumor acidosis targeted delivery of immunotherapy by Marker-Agnostic TumoR-Anchoring ChimerasFrom1 Aug 2025 → TodayFunding: HORIZON.1.1 - European Research Council (ERC)
- Cofunding core facility - CORE extracellulaire vesikelsFrom1 Jun 2025 → TodayFunding: BOF - research organisations
- Combating peritoneal metastasis by a sustained release triple chemo-immunotherapyFrom1 Apr 2025 → TodayFunding: FWO research project (including WEAVE projects)
- Selective Elimination of Senescent Tumor Cells for Enhanced Radio-immunotherapy with BRD4-Degrading Protein-Conjugated PROTAC ProdrugsFrom1 Jan 2025 → TodayFunding: International Cooperation and Mobility
- Effective Delivery of Nucleic Acid Therapeutics via Designed NanocarriersFrom1 Oct 2024 → TodayFunding: HORIZON.1.2 - Marie Skłodowska-Curie-actions (MSCA)
- A MALDI-TOF/TOF MS instrument for (bio)polymer characterization and imaging.From1 May 2024 → TodayFunding: FWO Medium Size Research Infrastructure
- ReHiFiNMR - Rejuvenation of High-Field NMR equipment for the continued and enhanced characterization of complex molecular architectures and their interactionsFrom1 May 2024 → TodayFunding: FWO Medium Size Research Infrastructure
- FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.From1 May 2024 → TodayFunding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 251
- Combinatorial synthesis and evaluation of trialkyl galloyl amidoamine ionizable lipids for mRNA formulation(2025)Published in: JOURNAL OF THE AMERICAN CHEMICAL SOCIETYISSN: 1520-5126Issue: 30Volume: 147Pages: 26934 - 26943
- Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo(2025)Published in: ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONISSN: 1521-3773Issue: 28Volume: 64
- A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity(2025)Published in: ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONISSN: 1521-3773Issue: 7Volume: 64
- A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells(2025)Published in: ADVANCED MATERIALSISSN: 1521-4095Issue: 11Volume: 37
- Development of tailored indole-blocked triazolinediones for site-selective bioconjugation(2025)Pages: XVI, 315 p.
- HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells(2024)Published in: CHEMISTRY OF MATERIALSISSN: 1520-5002Issue: 20Volume: 36Pages: 10113 - 10124
- Lipid nanoparticle formulation strategies for peptide-based cancer vaccines(2024)Pages: X, 208 p.
- Relevance of controlled cooling and freezing phases in T-cell cryopreservation(2024)Published in: CRYOBIOLOGYISSN: 1090-2392Volume: 116
- Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation(2024)Published in: ACS NANOISSN: 1936-086XIssue: 41Volume: 18Pages: 28311 - 28324
- Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity(2024)Published in: SMALLISSN: 1613-6829Issue: 10Volume: 20