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Researcher
Steven Van Cruchten
- Research Expertise:xxxxxxx
- Keywords:TOXICOLOGY, IN VITRO TESTS, EMBRYOTOXICITY, ANIMAL MODELS, Veterinary medicine
- Disciplines:Biomarker discovery, In vitro testing, Non-clinical studies, Veterinary medicine, Other veterinary sciences
- Research techniques:-omics, ELISA, immunohistochemistry, spectrophotometry, luminiscence, LC-MS
- Users of research expertise:CROs; chemical, pharma and biotech companies
Affiliations
- Comparative Perinatal Development (CoPeD) (Research group)
Responsible
From1 Sep 2024 → Today - Comparative Perinatal Development (CoPeD) (Research group)
Member
From1 Feb 2010 → 31 Aug 2024
Projects
1 - 10 of 19
- Functional Anatomy using Classical and Cutting-Edge Techniques (FAC²ET).From1 Jan 2025 → TodayFunding: FWO scientific research network
- Reducing Non-Human Primates in Non-Clinical Assessment: The European Initiative on Minipig and Micropig Models (NHPig).From1 Oct 2024 → TodayFunding: HORIZON.2.1 - Health
- Advancing the Zebrafish Embryo Developmental Toxicity Assay (ZEDTA) towards a sensitive screening assay.From1 Nov 2020 → 31 Oct 2023Funding: BOF - doctoral mandates
- Qualification of the juvenile minipig for pediatric safety testing of single stranded oligonucleotides (SSOs).From15 Jul 2020 → 14 Jul 2021Funding: BOF - doctoral mandates
- I-PREDICT: Innovative Physiology-based pharmacokinetic model to pREdict Drug exposure In neonates undergoing Cooling Therapy.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Advancing the zebrafish embryo developmental toxicity assay from screening to regulatory testing.From1 Nov 2019 → 31 Oct 2020Funding: BOF - doctoral mandates
- Assessment of skeletal endpoints and exposure in an extended Zebrafish Developmental Toxicity Assay (ZEDTA) using mammalian teratogens.From10 Apr 2018 → 9 Apr 2020Funding: Foreign public sponsor
- Bioactivation of human proteratogens in the zebrafish embryo model, a potential alternative test for development toxicity assessment.From1 Jan 2018 → 31 Dec 2021Funding: FWO Strategic Basic Research Grant
- Reaction phenotyping and CRISPR/Cas9 genome editing of xenobiotic CYP isoenzymes in the zebrafish embryo: effects on bioactivation of prodrugs and normal functioning.From1 Oct 2016 → 31 Dec 2017Funding: Fund Recuperation Fiscal Exemption
- Construction and activity of recombinant cythochrome P450 enzymes as an in vitro system for reaction-phenotyping of drug candidates in the Göttingen minipig.From18 Jul 2016 → 31 Dec 2017Funding: Foreign foundations, funds with scientific view
Publications
1 - 10 of 101
- New approach methodologies for assessing developmental toxicity of pharmaceuticals: case examples and future directions(2025)Published in: Reproductive toxicologyISSN: 0890-6238Volume: 137Pages: 1 - 8
- Considerations for use of humanized IgG1/4 Göttingen minipigs in safety assessment of antibody-based therapeutics(2025)Published in: Regulatory toxicology and pharmacologyISSN: 0273-2300Volume: 161Pages: 1 - 5
- Effects of hypothermia and hypoxia on cytochrome P450-mediated drug metabolism in neonatal Göttingen minipigs(2024)Published in: Basic and clinical pharmacology and toxicologyISSN: 1742-7835Volume: 135Pages: 620 - 640
- Review of dose setting for the extended one-generation reproductive toxicity studies (OECD TG 443): considerations on ECHA's dose level selection recommendations(2024)Published in: Regulatory toxicology and pharmacologyISSN: 0273-2300Volume: 151Pages: 1 - 4
- Integrated approaches in pediatric pharmacotherapy: the neonatal Göttingen minipig model for drug disposition in perinatal asphyxia and therapeutic hypothermia(2024)Number of pages: 227
- The use of Göttingen minipigs in juvenile studies(2024)Pages: 1 - 19
- HESI workshop summary: interpretation of developmental and reproductive toxicity endpoints and the impact on data interpretation of adverse events(2024)Published in: Birth defects researchISSN: 2472-1727Volume: 116Pages: 1 - 11
- Biological variability hampers the use of skeletal staining methods in zebrafish embryo developmental toxicity assays(2024)Published in: Reproductive toxicologyISSN: 0890-6238Volume: 127Pages: 1 - 25
- Cell migration and proliferation capacity of IPEC-J2 cells after short-chain fatty acid exposure(2024)Published in: PLoS ONEISSN: 1932-6203Volume: 19Pages: 1 - 15
- Thriving or striving: comparing intra-uterine growth restricted, low birth weight and normal birth weight piglets within the first 24 hours(2024)Published in: AnimalsISSN: 2076-2615Volume: 14Pages: 1 - 18