Synthesis, Characterization and Biological Evaluation Against Influenza Virus Agonists of (N′E,N′"E)-2,2′-[[1,1′-Biphenyl]-4,4′-dihylbis(oxy)]bis (N′-arylmethyleneacetohydrazides)

Abstract:N',N'''-[2,2'-[[1,1'-Biphenyl]-4,4'-diylbis(oxy)]bis(acetyl)] di(benzohydrazide) 3 was prepared by reaction of 2,2'-[1,1'-biphenyl]-4,4'- diylbis(oxy)]bisacetohydrazide 2 with benzoyl chloride. A new series of the arylidene 4-15 was prepared by heating 2 with the following aldehydes: 4-flourobenzaldehyde, p-tolualdehyde, 2-hydroxy-3- methoxybenzaldehyde, 2-chlorobenzaldehyde, isonicotinaldehyde (4-pyridine carboxaldehyde), benzaldehyde, 4- chlorobenzaldehyde, picolinaldehyde (2-pyridine carboxaldehyde), 4-methoxybenzaldehyde (4-anisaldehyde), 3- bromobenzaldehyde, 2,4,6-trimethoxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde (vaniline). The compounds were evaluated against influenza virus. Two compounds showed moderate activity which means that with more derivatization, better activity could be expected. © 2014 Bentham Science Publishers.

Publication year:2014

Keywords:Organic & medicinal chemistry

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:0.1

CSS-citation score:1

Authors:International

Authors from:Higher Education

Review status:Peer-reviewed