The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice

Congenital thrombotic thrombocytopenic purpura (TTP) is characterized by mutations in the ADAMTS13 gene, which impair either protein secretion or influence ADAMTS13 activity. Phenotypic consequences of these mutations have not yet been evaluated in animal models for TTP.

Publication year:2015

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BOF-publication weight:3

CSS-citation score:1

Authors:International

Authors from:Higher Education

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