Somatic mutations leading to CD8+T cell proliferation contribute to the pathogenesis of multiple sclerosis

Following on the development and validation of the pipeline and the proof-of-concept in MS (multiple sclerosis), l will now investigate whether and how somatic mutations contribute to the pathogenesis of MS. In particular, l will investigate whether these cells are pathogenic, confer a particular inflammatory or proliferative phenotype, and have the ability to migrate into the CNS. If proven to be pathogenic, they can indicate new targets tor therapy and provide genetic tests for precision medicine, i.e. assist treatment choice and follow-up of treatment effect. The overall objective translates into four aims - each corresponding to a work package.