Imaging the link between metabotropic and ionotropic signaling in vivo

Cellular communication is a prerequisite for the life of multicellular organisms. Evolution has given rise to a variety of messenger systems that differ in speed and range. The communication between the outside and the inside of a cell is a key interface that is largely orchestrated by transmembrane receptors. This family of communication proteins can be roughly divided into two classes: 1) Metabotropic receptors, which trigger intracellular second messenger signaling cascades and 2) ionotropic receptors, which allow ions to cross the cell membrane. The goal of the proposed research is to visualize the cross-talk between these communication channels in vivo.

Keywords:ionotropic

Disciplines:Other biological sciences