Socio-affective communication through ultrasonic vocalizations in rodents: Improving translational research models for neuropsychiatric dysfunctions

Modeling human neuropsychiatric dysfunctions in rodents is an extremely daunting challenge, given the subjective nature of many symptoms, the lack of relevant biomarkers and objective diagnostic tools, together with the early state of the pertinent neurobiology and genetics. In fact, the identification of new therapeutic targets is at a near standstill. I am convinced that a deeper understanding of the natural rodent behavior repertoire and its relevance for modeling human neuropsychiatric dysfunctions is needed to overcome current limitations of translational research. I will improve translational research models for neuropsychiatric dysfunctions by deciphering socio-affective communication through ultrasonic vocalizations (USV) in rodents. I will reach that goal by means of a neuroethology driven strategy including technological innovations, e.g. a body microphone for continuous real-time monitoring of USV emission in rats. Deciphering socio-affective communication through USV in rodents will refine biomedical research.

Keywords:Animal models, Neuropsychiatric disorders, Ultrasonic vocalizations

Disciplines:Animal experimental psychology