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Patent
Human ntcp binders for therapeutic use and liver-specific targeted delivery
The disclosure relates to binding agents and compositions specifically binding the human Na+-taurocholate co-transporting polypeptide (NTCP/ SLC10A1), thereby stabilizing a NTCP conformational state which allosterically inhibits its bile salt transport function. More specifically, the disclosure discloses Nanobodies that lock an inward-facing or open-pore NTCP conformational state, thereby useful as novel hepatitis virus B (HBV) and/or hepatitis virus D (HDV) antiviral, for treatment of liver disease, or as vehicle for targeted-delivery to the liver. Finally, the disclosure relates to a screening assay wherein said Nanobodies are used as a tool to identify NTCP conformation-selective compounds with therapeutic potential.
Patent Publication Number: EP4463479A
Source: EPO
Year publication: 2024
Status: Requested
URI: link to Espacenet
Technology domains: undefined