Method for determining responsiveness to an epitope

Method (100) for determining an immune responsiveness to a query epitope (126) comprising: receiving sequence data (122) comprising TCR sequences of at least a part of a TCR repertoire of a subject; selecting a predictive model (160) generated or trained using a dataset comprising TCR sequences known to bind specifically to a model epitope, said predictive model selected according to a sequence match between the model epitope and query epitope; querying (130) the selected predictive model (160) with the sequence data (122); determining (140) from outputs of the selected predictive model (160) a Responsiveness Score indicative of the immune responsiveness. The immune responsiveness can be used to predict and optimal vaccine composition and/or evaluate efficacy of a vaccine in a subject or population.

Patent Publication Number: WO2020174077

Year filing: 2020

Year approval: 2021

Year publication: 2020

Status: Requested

Technology domains: undefined

Validated for IOF-key: Yes

Attributed to: Associatie Universiteit & Hogescholen Antwerpen