< Back to previous page


Dynamic monitoring and risk assessment of chronic fatigue in survivors of childhood cancer.

As survival rates have increased tremendously in children and

adolescents treated for cancer, the long-term sequelae of the

childhood cancer treatment play an increasingly important role in

their daily life quality. A frequently experienced symptom is a chronic

feeling of fatigue, of which the prevalence reaches up to 85% in

childhood cancer survivors.

Although this has a large negative impact on daily life functioning of

the patient, to date there is no standard of care to monitor this, or

even to reduce it. Mind-body interventions are strongly recommended

at international level. However, a behavioral intervention only

becomes efficient if we can intervene adequately and instantly at the

moment, in the context, with fatigue-reducing exercises according to

the needs of the patient. Since cancer-related fatigue is a fluctuating

symptom, it is thus required to determine the dynamic risk factors in


Therefore, this project focuses on the identification of patient- and

time-related risk factors for developing long-term fatigue in 150

childhood cancer survivors.

We wish to monitor the patient's psychological experiences (e.g.

fatigue, anxiety, depression), as well as the physiological,

environmental and stress-related parameters. By implementing a

wearable and an app-based daily life emotional survey (“Experience

Sampling”), we can address the dynamic associations between

fatigue, stress, worrying behavior, insomnia, decreased physical

activity, and biological changes.

Date:1 Jan 2021  →  Today
Keywords:Chronic Fatigue, Dynamic risk assessment, childhood cancer sequelae
Disciplines:Behavioural sciences, Biological psychiatry, Psychophysiology, Social and emotional development, Behavioural neuroscience