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Project

Nanoparticles as Delivery Vehicles for Gene Transport to the Tumor Microenvironment and Endothelial Cells

As conventional cancer therapies often result in severe side effects and ineffective treatment, new tumor targeting strategies are being investigated. Still, the delivery of therapeutically active nanomaterials to the tumor microenvironment (TME) has been found to be challenging. In most cases, those therapies focus only on targeting cancer cells, even though the full TME, including immune cells and endothelial cells (ECs), are of importance in cancer progression and efficiency of treatment. Here, we aim to focus on a different approach, namely novel combinatorial therapies to manipulate gene expression in both cancer cells and ECs using lipid nanoparticles (LNPs). For this purpose, two different formulations are needed: (i) LNPs targeting cancer cells, whilst creating an immunogenic TME, and (ii) LNPs targeting ECs for the transport of RNA/DNA molecules. The optimal combination strategy of both therapies will be tested in challenging cancer models where off-targeting is tried to be kept to a minimum.

Date:1 Mar 2019 →  Today
Keywords:nanomedicine, drug delivery
Disciplines:Biomaterials engineering not elsewhere classified
Project type:PhD project