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Researcher
Maarten Dewilde
- Disciplines:Gene and molecular therapy, Medical molecular engineering of nucleic acids and proteins, Compound screening, In vitro testing, Non-clinical studies
Affiliations
- Therapeutic and Diagnostic Antibodies (Division)
Responsible
From1 Apr 2023 → Today - Therapeutic and Diagnostic Antibodies (Division)
Member
From1 Oct 2020 → Today
Projects
1 - 10 of 21
- RETROFIT platform: Toward reverse translational discovery & designing of next-generation immunotherapies against immuno-resistant tumoursFrom1 Oct 2025 → TodayFunding: FWO Strategic Basic Research (SBO)
- Strategies to deliver oligonucleotide based drugs to the brainFrom25 Sep 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating the mechanisms of anti-amyloid antibodies and the role of microglia in amyloid plaque clearance in Alzheimer’s DiseaseFrom22 Sep 2025 → TodayFunding: FWO fellowships
- Brain specific drug delivery of biologicalsFrom22 Sep 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Accurate assessment of biomolecular interactions during basic research and drug development.From1 Jan 2025 → TodayFunding: BOF - scientific equipment program
- Accurate assessment of biomolecular interactions during basic research and drug development.From1 Jan 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Behind the barrier: how to extend the half-life of biologicals in the brain?From1 Mar 2024 → 28 Feb 2025Funding: IOF - technology validation in lab
- MabMine: Breaking the barrier in conventional antibody discoveryFrom1 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Improving specificity in gene therapy through nanobody coupling of AAV vectors.From1 Jan 2023 → 31 Dec 2023Funding: IOF - technology validation in lab
- PhD candidate to optimize the delivery of biologicals (antibodies) to the brainFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 26
- From computational design to synthetic antibodies: a rational approach to antibody discovery(2025)
- The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia(2025)Published in: Nature NeuroscienceISSN: 1097-6256
- A versatile platform for combinatorial antibody library cloning and NGS-based quality control with high accuracy(2025)Published in: Nucleic Acids ResearchISSN: 0305-1048Issue: 19Volume: 53
- A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies(2025)Published in: ElifeISSN: 2050-084XVolume: 14
- The road to innovative antibody therapy: DNA-based delivery and brain half-life extension of antibodies(2025)
- Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease(2025)Published in: Alzheimers & DementiaISSN: 1552-5260Issue: 4Volume: 21
- Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein(2025)Published in: Fluids Barriers CNSISSN: 2045-8118Issue: 1Volume: 22
- Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model(2025)Published in: BrainISSN: 0006-8950Issue: 3Volume: 148Pages: 941 - 954
- Basic Science and Pathogenesis.(2024)Published in: Alzheimers & DementiaISSN: 1552-5260Volume: 20 Suppl 1Pages: e087213
- Microfluidic Interfaces for Chronic Bidirectional Access to the Brain(2024)Published in: Advanced Healthcare MaterialsISSN: 2192-2640Issue: 22Volume: 13
Linked dataset
1 - 4 of 4
- Illumina Raw Data for: A versatile platform for combinatorial antibody library cloning and NGS based quality control with high accuracy
- Replication Data for: Increasing brain half-life of antibodies by additional binding to myelin-oligodendrocyte glycoprotein, a CNS specific protein
- Replication Data for Exploring the fate of antibody-encoding pDNA after intramuscular electroporation in mice
- Replication Data for: ‘Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics‘