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Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Infrastructure
1 - 1 of 1
Projects
1 - 10 of 42
- Acquisition of a cryo-holder for an existing JEOL F200 electron microscope to enable structural biology applications in the context of human diseaseFrom1 Jan 2025 → TodayFunding: BOF - scientific equipment program
- Acquisition of a cryo-holder for an existing JEOL F200 electron microscope to enable structural biology applications in the context of human diseaseFrom1 Jan 2025 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Elucidating the molecular architecture of intermediate filaments through chemical cross-linking and modelling.From1 Oct 2024 → TodayFunding: FWO fellowships
- Activating negative regulators of KRAS signaling as a novel anticancer paradigmFrom1 Oct 2024 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom5 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 105
- Crystal engineering of the hepatoma-derived growth factor-related protein 2 PWWP domain towards crystallographic fragment screening(2025)Published in: Acta Crystallographica F, Structural Biology and Crystallization Communications OnlineISSN: 2053-230XIssue: Pt 8Volume: 81Pages: 358 - 364
- DDtrek: A PyMOL-Based Management System for 3D Structural Data Series(2025)Published in: ACS OmegaISSN: 2470-1343Issue: 21Volume: 10Pages: 21024 - 21029
- Rational fragment-based design of compounds targeting the PWWP domain of the HRP family(2024)Published in: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 280
- CCDC158: A novel regulator in renal proximal tubular endocytosis unveiled through exome sequencing and interactome analysis(2024)Published in: Journal of Cellular PhysiologyISSN: 0021-9541Issue: 12Volume: 239
- Molecular structure of soluble vimentin tetramers (vol 13, 8841, 2023)(2024)Published in: Scientific ReportsISSN: 2045-2322Issue: 1Volume: 14
- A high-throughput target-based screening approach for the identification and assessment of Mycobacterium tuberculosis mycothione reductase inhibitors(2024)Published in: Microbiology SpectrumISSN: 2165-0497Issue: 3Volume: 12
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors(2023)
- Molecular structure of soluble vimentin tetramers(2023)Published in: Scientific ReportsISSN: 2045-2322Issue: 1Volume: 13
- Novel Insights Into Intermediate Filament Assembly Through Chemical Cross-Linking(2023)
- 5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro(2023)Published in: Antiviral ResISSN: 0166-3542Volume: 209