Cancers develop due to the accumulation of somatic mutations in the genome. The Laboratory for Cancer Genomics studies these mutations and leverages them to elucidate the evolutionary history of cancers. In this endeavour, we make use of new sequencing technologies and new bioinformatics analysis approaches.
Laboratory for Genomics of Structural Congenital Disorders
The Lab for Integrative cancer Genomics develops computational approaches to comprehensively chart genomic and epigenetic variation using sequencing data and elucidate their contributions to somatic evolution, tumour heterogeneity, and treatment resistance.
Our group focuses on:
(1) The development of wet-lab and computational methods for single-cell multi-omics analyses –including genome, epigenome and transcriptome analyses of single cells– using microarray and next-generation sequencing technologies. We furthermore automate these methods using customised liquid handling robotics and microfluidics.
(2) The application of these methods to study the nature, rate and mechanisms of ...
The core business of REGE is the interphase between reproduction and genetics, a wide discipline covering several subdisciplines. Male infertility and the search for genes involved in spermatogenensis is a first topic that is mainly investigated within the Centre for Medical Genetics. A second important topic covers the (epi)genetics of embryos and embryonic stem cells, amongst others the investigation of chromosomal abnormalities, epigenetic ...
In this research area, we survey the genetic diversity, habitat and evolution over time of plant populations. Relationships between and among genetic sources are applied to breeding. This breeding research includes development and use of molecular markers, embryo rescue, polyploidization and protoplast fusion. We make (interspecific) crosses with improved disease resistance, better use of nutrients, drought resistance, and more.
Topic A : Identification of new mutations in hereditary diseases (W. Lissens, I. Liebaers), more in particular: - cystic fibrosis - iduronate sulphate deficiency - Beta-glucuronidase deficiency - anti thrombosis III deficiency Topic B : Preimplantation genetics/expression (Liebaers I, Lissens W.) - expression Beta-hexosaminidase in mouse and human embryo's - preimplantation diagnosis in couples at risk for cysticfibrosis (F508) or couples at ...
Research topics of this unit are:
• Bacteria-plant interactions
• Symbiosis between Rhizobium etli and Phaseolus vulgaris
• Symbiotic nitrogen fixation
• Quorum sensing and biofilm formation in Rhizobium
• Bacterial physiology: the stringent response in Rhizobium
• Type III protein secretion in Rhizobium
• Calcium-binding proteins in bacteria
• Mechanisms of antibiotic resistance and tolerance in Pseudomonas ...
The Divsion for Clinical Genetics has two research fields: