Projects
Mast cells as modulators of the extracellular matrix to promote regeneration after spinal cord injury. Hasselt University
Modelling of gene networks for steering of biomimetic production processes in tissue engineering. KU Leuven
The specialization of cartilage cells, or chondrogenic differentiation, is an intricate and meticulously regulated process that plays a vital role in both bone formation and cartilage regeneration. This PhD work centers on the development of computational models to study the molecular regulation of this process. First, we investigate how individual genes and their defects contribute to the overall change in functionality of the growth plate, ...
The Interprosthetic Gap as a Risk Factor for Interprosthetic Fractures of the Femur KU Leuven
An interprosthetic (IP) gap is created when an arthroplasty is performed on both joints of the same bone to replace deteriorated joints. Specifically in this
thesis, placement of a hip and knee prosthesis in the femur was examined. Such an ipsilateral placement of stemmed prostheses into the same bone creates a gap of varying size and location depending on the prosthesis stem lengths. The IP gap is measured in between the tips of the ...
Multi-scale modeling in bone tissue enginnering: from biomaterials to intracellular signaling via the cell. KU Leuven
Intratendinous strain distribution in Achilles tendon and tendinosis. KU Leuven
The role of human dental pulp stem cells (hDPSC) in angiogenesis and bone tissue engineering. Hasselt University
Improved safety for minimally invasive surgery by incalculation of pathology-specific acute and chronic effects of tissue manipulation. KU Leuven
The lack of intraoperative haptic feedback limits the benefits that are associated with robotic minimally invasive surgery. The development of mathematical models to implement force information in surgical robots requires biological data describing the relationship between mechanical loading and consequential tissue damage. In this dissertation we aimed to quantify this relationship for aortic clamping, a procedure that is often crucial ...